The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 5-fluoro-3-pyridinecarboxylate( cas:455-70-9 ) is researched.Electric Literature of C7H6FNO2.Lee, Hong Geun; Milner, Phillip J.; Buchwald, Stephen L. published the article 《An Improved Catalyst System for the Pd-Catalyzed Fluorination of (Hetero)Aryl Triflates》 about this compound( cas:455-70-9 ) in Organic Letters. Keywords: palladium AdBrettPhos catalyzed fluorination aryl heteroaryl triflate. Let’s learn more about this compound (cas:455-70-9).
The stable Pd(0) species [(1,5-cyclooctadiene)(L·Pd)2] (L = AdBrettPhos, I, R = adamantyl) has been prepared and successfully evaluated as a precatalyst for the fluorination of aryl triflates derived from biol. active and heteroaryl phenols, challenging substrates for our previously reported catalyst system [e.g., estrone triflate → 3-fluorodeoxyestrone in 74% yield and >20:1 regioselectivity]. Addnl., this precatalyst activates at room temperature under neutral conditions, generates 1,5-cyclooctadiene as the only byproduct, and leads to overall cleaner reaction profiles.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem