The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 3458-28-4, Name is (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, SMILES is O=C[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O, in an article , author is Bannister, R, once mentioned of 3458-28-4, COA of Formula: https://www.ambeed.com/products/3458-28-4.html.
The synthesis of [3aR,4S,6R,6aS]-6-amino-N-ethyltetrahydro-2,2-dimethyl -4H-cyclopenta-1,3-dioxole-4-carboxamide, a key single enantiomer intermediate to carbocyclic nucleosides such as adenosine agonists, is reported involving a scalable catalytic osmium tetraoxide dihydroxylation of (-)-2-azabicyclo[2.2.1]hept-5-en-3-one. The acetonide-protected diol [3aS,4R,7S,7aR]-tetrahydro-2,2-dimethyl-4,7-methano-1,3-dioxolo [4,5-c]pyridin-6(3aH)-one is subject to lactam ring opening with anhydrous ethylamine to give the carbocyclic key intermediate, The rate of this known reaction, carried out in a pressure vessel, is considerably enhanced by acid catalysis using ethylammonium ion, In addition, the need for a pressure vessel is circumvented by using anhydrous ethylamine with acid catalysis, Alternatively stoichiometric ethylammonium ion in an appropriate cosolvent can be used to form the key intermediate in high yield.
COA of Formula: https://www.ambeed.com/products/3458-28-4.html, You can get involved in discussing the latest developments in this exciting area about 3458-28-4.
Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem