The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis and Antibacterial Activity of a Novel Series of 2,3-Diaryl-substituted-imidazo(2,1-b)-benzothiazole Derivatives》. Authors are Palkar, Mahesh; Noolvi, Malleshappa; Sankangoud, Ramappa; Maddi, Veeresh; Gadad, Andanappa; Nargund, Laxmi Venkat G..The article about the compound:6,7-Dichlorobenzo[d]thiazol-2-aminecas:25150-27-0,SMILESS:NC1=NC2=CC=C(Cl)C(Cl)=C2S1).Formula: C7H4Cl2N2S. Through the article, more information about this compound (cas:25150-27-0) is conveyed.
Benzothiazole and imidazole compounds are extensively studied heterocyclics due to their wide spectrum of bioactivities. Among them, the imidazo(2,1-b)-benzothiazole derivatives are pharmacol. important because of their immunostimulant, anti-inflammatory, antifungal, antimicrobial, antitumor, and other activities. In the present research work, a novel series of 2,3-diaryl-substituted imidazo(2,1-b)-benzothiazoles 13a-o have been synthesized by reaction of substituted 2-aminobenzothiazoles 1-8 and an appropriately substituted α-bromo-1-(4”-substituted)-phenyl-2-(4′-substituted)-phenyl-1-ethanones 9-12 in the presence of anhydrous acetonitrile. They were characterized by physicochem., elemental, and spectral (IR, 1H-NMR, and Mass) data. All the synthesized compounds were screened for their in-vitro antibacterial activity against Gram-pos., Gram-neg. bacteria. The investigation of antibacterial screening data revealed that most of the compounds tested have demonstrated congruent activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standard ampicillin. Among the series, compounds 13d, 13h, and 13m exhibited excellent an antibacterial activity profile as compared with the standard In summary, preliminary results indicate that some of the newly synthesized title compounds exhibited promising antibacterial activities and they warrant more consideration as prospective antimicrobials.
Compound(25150-27-0)Formula: C7H4Cl2N2S received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(6,7-Dichlorobenzo[d]thiazol-2-amine), if you are interested, you can check out my other related articles.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem