Synthesis and biological screening of S-substituted derivatives of 5-{1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl}-1,3,4-oxadiazol-2-yl sulfide was written by Nafeesa, Khadija;Aziz-ur-Rehman;Abbasi, M. Athar;Siddiqui, Sabahat Z.;Rasool, Shahid;Hussain, Ghulam;Ahmed, Irshad. And the article was included in Asian Journal of Chemistry in 2015.Electric Literature of C4H7BrO2 This article mentions the following:
In present research, a novel series of S-substituted derivatives of 5-[1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl]-1,3,4-oxadiazole-2-thiol I [R = (CH2)2Br, i-Pr, s-Bu, etc.] were synthesized by a multistep protocol starting from Et piperidine-3-carboxylate, which reacted with (4-chlorobenzene)sulfonyl chloride. The resulting Et 1-[(4-chlorophenyl)sulfonyl]piperidine-3-carboxylate was subsequently converted into its corresponding carbohydrazide and then to the 2,5-disubstituted-1,3,4-oxadiazole by intermol. cyclization. The compound 5-[1-(4-chlorophenylsulfonyl)-3-piperidinyl]-1,3,4-oxadiazole-2-thiol was derivatized by different alkyl halides. All of the synthesized compounds were screened for antibacterial activity and enzyme inhibition potential against lipoxygenase enzyme. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Electric Literature of C4H7BrO2).
2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C4H7BrO2
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem