The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine( cas:1265884-98-7 ) is researched.Formula: C34H22NO2P.Jiang, Shi-Zhi; Zeng, Xue-Yi; Liang, Xiao; Lei, Ting; Wei, Kun; Yang, Yu-Rong published the article 《Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-Aspidophylline A》 about this compound( cas:1265884-98-7 ) in Angewandte Chemie, International Edition. Keywords: iridium catalyzed enantioselective indole cyclization aspidophylline A synthesis; absolute configuration aspidophylline A; enantioselective indole allylic alkylation iminium cyclization cascade; cyclizations; enantioselectivity; indoles; iridium; total synthesis. Let’s learn more about this compound (cas:1265884-98-7).
The first enantioselective total synthesis of (-)-aspidophylline A (I), including assignment of its absolute configuration has been accomplished. A key element of the synthesis is a highly enantioselective indole allylic alkylation/iminium cyclization cascade which was developed by employing a combination of Lewis acid activation and an iridium/ligand catalyst. This strategy relies on the direct use of 2,3-disubstituted indoles with secondary allylic alcs. appended at C2 and heteronucleophiles appended at C3, indoles which are easily prepared from simple starting materials under C-H activation conditions.
Compounds in my other articles are similar to this one(5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine)Formula: C34H22NO2P, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem