Participation of hippocampal ionotropic glutamate receptors in histamine H1 antagonist-induced memory deficit in rats was written by Masuoka, Takayoshi;Saito, Shunsuke;Kamei, Chiaki. And the article was included in Psychopharmacology (Berlin, Germany) in 2008.Related Products of 34023-62-6 This article mentions the following:
Pyrilamine, a selective histamine H1 antagonist, impaired spatial memory, and decreased hippocampal theta activity during a radial maze task. We investigated the ameliorative effects of glutamatergic drugs on pyrilamine-induced spatial memory deficit and the decrease in hippocampal theta activity in rats. Drug effects were measured using an eight-arm radial maze with four arms baited. Hippocampal theta rhythm during the radial maze task was also recorded with a polygraph system using a telemetric technique. I.p. injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and a decrease in the amplitude and power of hippocampal theta waves. The working memory deficit and the decrease in hippocampal theta power were antagonized by intrahippocampal injection of d-cycloserine (1 μg/side), spermidine (10 μg/side), spermine (10 μg/side), aniracetam (1 μg/side), and 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP) (1 μg/side), but not Con A. These results clearly indicate that H1 antagonist-induced working memory deficit, and the decrease in hippocampal theta activity was closely associated with hippocampal glutamatergic neurotransmission mediated by N-methyl-
Benzo[d][1,3]dioxol-5-yl(piperidin-1-yl)methanone (cas: 34023-62-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 34023-62-6
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem