Selective, Orally Active 5-HT1D Receptor Agonists as Potential Antimigraine Agents was written by MacLeod, Angus M.;Street, Leslie J.;Reeve, Austin;Jelley, Richard A.;Sternfeld, Francine;Beer, Margaret S.;Stanton, Josephine A.;Watt, Alan P.;Rathbone, Denise;Matassa, Victor G.. And the article was included in Journal of Medicinal Chemistry in 1997.Category: dioxole This article mentions the following:
The clin. effective antimigraine drug, sumatriptan, is a serotonin receptor agonist with equal affinity for the 5-HT1B and 5-HT1D subtypes. To determine whether a compound selective for the 5-HT1D subtype would have the same clin. efficacy, but with reduced side effects, a structural exploration of non-selective compounds was carried out to identify features that would provide differential binding affinity for the two receptors. Functionalized piperazinylpropylindoles were shown to have high affinity for 5-HT1D with binding selectivities greater than 100-fold with respect to 5-HT1B. The meta-fluorophenethylpiperazine L-775,606 was highlighted as the first orally bioavailable, selective 5-HT1D agonist. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Category: dioxole).
2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem