The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromomethyl-1,3-dioxolane(SMILESS: BrCC1OCCO1,cas:4360-63-8) is researched.Name: (2R)-1-[(1R)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene. The article 《Iridium-catalyzed acid-assisted asymmetric hydrogenation of oximes to hydroxylamines》 in relation to this compound, is published in Science (Washington, DC, United States). Let’s take a look at the latest research on this compound (cas:4360-63-8).
Asym. hydrogenations are among the most practical methods for the synthesis of chiral building blocks at industrial scale. The selective reduction of an oxime to the corresponding chiral hydroxylamine derivative remains a challenging variant because of undesired cleavage of the weak nitrogen-oxygen bond. We report a robust cyclometalated iridium(III) complex bearing a chiral cyclopentadienyl ligand as an efficient catalyst for this reaction operating under highly acidic conditions. Valuable N-alkoxy amines can be accessed at room temperature with nondetected overredn. of the N-O bond [e.g., (E)-I → (S)-II (97%, 97.5:2.5 er)]. Catalyst turnover numbers up to 4000 and enantiomeric ratios up to 98:2 are observed The findings serve as a blueprint for the development of metal-catalyzed enantioselective hydrogenations of challenging substrates.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem