Effect of N-alkylation on the affinities of analogs of spiperone for dopamine D2 and serotonin 5-HT2 receptors was written by Mach, Robert H.;Jackson, Joseph R.;Luedtke, Robert R.;Ivins, Kathryn J.;Molinoff, Perry B.;Ehrenkaufer, Richard L.. And the article was included in Journal of Medicinal Chemistry in 1992.Formula: C12H14ClFO2 This article mentions the following:
Two series of N-substituted spiperone analogs were prepared and evaluated in vitro to measure their affinities for dopamine D2 and serotonin 5-HT2 receptors. Substitution of the amide N with an alkyl group of 5 carbon units or less resulted in analogs displaying a low selectivity for D2 compared to 5-HT2 receptors. However, a moderate improvement in selectivity for D2 receptors was observed with N-benzylspiperone. Substitution at either the ortho or para position of the benzyl group resulted in a further reduction in affinity for 5-HT2 receptors and improvement in the selectivity ratio. Examination of N-substituted analogs of spiperone may provide insights into the topog. of the antagonist binding region of the 5-HT2 receptor. The results also suggest that an 18F-labeled analog of N-(4-nitrobenzyl)spiperone may be a suitable tracer for studying D2 receptors with positron emission tomog. since this compound displays a high selectivity for D2 receptors relative to that of spiperone and N-methylspiperone. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Formula: C12H14ClFO2).
2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem