Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-antimycobacterial activities was written by Macaev, Fliur;Rusu, Ghenadie;Pogrebnoi, Serghei;Gudima, Alexandru;Stingaci, Eugenia;Vlad, Ludmila;Shvets, Nathaly;Kandemirli, Fatma;Dimoglo, Anatholy;Reynolds, Robert. And the article was included in Bioorganic & Medicinal Chemistry in 2005.SDS of cas: 3418-21-1 This article mentions the following:
The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the computer-aided study of their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topol. method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1SDS of cas: 3418-21-1).
2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 3418-21-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem