Liu, Pan published the artcilePhenylalanine Metabolism Is Dysregulated in Human Hippocampus with Alzheimer′s Disease Related Pathological Changes, COA of Formula: C16H10O5, the publication is Journal of Alzheimer’s Disease (2021), 83(2), 609-622, database is CAplus and MEDLINE.
Alzheimer′s disease (AD) is one of the most challenging diseases causing an increasing burden worldwide. Although the neuropathol. diagnosis of AD has been established for many years, the metabolic changes in neuropathol. diagnosed AD samples have not been fully investigated. To elucidate the potential metabolism dysregulation in the postmortem human brain samples assessed by AD related pathol. examination We performed untargeted and targeted metabolomics in 44 postmortem human brain tissues. The metabolic differences in the hippocampus between AD group and control (NC) group were compared. The results show that a pervasive metabolic dysregulation including phenylalanine metabolism, valine, leucine, and isoleucine biosynthesis, biotin metabolism, and purine metabolism are associated with AD pathol. Targeted metabolomics reveal that phenylalanine, phenylpyruvic acid, and N-acetyl-L-phenylalanine are upregulated in AD samples. In addition, the enzyme IL-4I1 catalyzing transformation from phenylalanine to phenylpyruvic acid is also upregulated in AD samples. There is a pervasive metabolic dysregulation in hippocampus with AD-related pathol. changes. Our study suggests that the dysregulation of phenylalanine metabolism in hippocampus may be an important pathogenesis for AD pathol. formation.
Journal of Alzheimer’s Disease published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, COA of Formula: C16H10O5.
Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem