Little discovery in the laboratory: a new route for 305798-02-1

There is still a lot of research devoted to this compound(SMILES：BrCC1=CC2=CC=C(Br)C=C2C=C1)HPLC of Formula: 305798-02-1, and with the development of science, more effects of this compound(305798-02-1) can be discovered.

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromo-6-(bromomethyl)naphthalene( cas:305798-02-1 ) is researched.HPLC of Formula: 305798-02-1.Zore, Matej; Gilbert-Girard, Shella; Reigada, Ines; Patel, Jayendra Z.; Savijoki, Kirsi; Fallarero, Adyary; Yli-Kauhaluoma, Jari published the article 《Synthesis and Biological Evaluation of Fingolimod Derivatives as Antibacterial Agents》 about this compound( cas:305798-02-1 ) in ACS Omega. Keywords: fingolimod preparation antibacterial anticancer human. Let’s learn more about this compound (cas:305798-02-1).

To study if the antibacterial activity of fingolimod could be further improved and to explore in-depth structure-activity relationships, 28 novel fingolimod derivatives I [R1 = 4-PhCH2C6H4, 4-OBnC6H4, 5-octyl-2-pyridyl, etc.; n = 1, 2], II [R2 = octyl, decyl] and III [R3 = H, octyl, decyl; R4 = H, octyl; Z = CH, N; m = 1, 2] were synthesized and evaluated their efficacy against Staphylococcus aureus grown in planktonic/single cell and biofilms. The most effective derivatives were tested on preformed S. aureus biofilms and against Gram-neg. bacteria Acinetobacter baumannii and Pseudomonas aeruginosa, using fingolimod as the reference compound Seven derivatives were more effective against S. aureus, while five other derivatives showed improved activity against P. aeruginosa and/or A. baumannii, with no apparent change in cytotoxicity on human cells. The most interesting derivatives, compounds I [R1 = 3-octylphenyl, n = 2] and II [R2 = decyl], displayed a broader spectrum of antibacterial activity, possibly exerted by the change of the para-hydrocarbon chain to a meta position for compound I [R1 = 3-octylphenyl, n = 2] and by an addnl. hydroxyl group for compound II [R2 = decyl].

There is still a lot of research devoted to this compound(SMILES：BrCC1=CC2=CC=C(Br)C=C2C=C1)HPLC of Formula: 305798-02-1, and with the development of science, more effects of this compound(305798-02-1) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem