Total Synthesis of Disciformycin A and B: Unusually Exigent Targets of Biological Significance was written by Kwon, Yonghoon;Schulthoff, Saskia;Dao, Quang Minh;Wirtz, Conny;Fuerstner, Alois. And the article was included in Chemistry – A European Journal in 2018.SDS of cas: 15186-48-8 This article mentions the following:
The first total synthesis of the potent antibiotic disciformycin B is described, which is exceptionally isomerization-prone and transforms into disciformycin A even under notably mild conditions. To outweigh this bias, the approach to disciformycin B hinged on the use of a silyl residue at C4 to lock the critical double bond in place and hence insure the integrity of the synthetic intermediates en route to disciformycin B. This tactic was instrumental for the preparation of the building blocks and formation of the macrocyclic ring via ring closing alkyne metathesis. To make the end game successful, however, it proved necessary to cleave the C-silyl protecting group off; it was at this stage that the exceptional sensitivity of the target became fully apparent. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8SDS of cas: 15186-48-8).
(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 15186-48-8
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem