Massive Parallel Catalyst Screening: Toward Asymmetric MCRs was written by Kusebauch, Ulrike;Beck, Barbara;Messer, Kim;Herdtweck, Eberhardt;Doemling, Alexander. And the article was included in Organic Letters in 2003.Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) This article mentions the following:
Hundreds of Lewis acid/ligand combinations have been screened for stereochem. induction in the Passerini multicomponent reaction. The combination of titanium tetraisopropoxide and (4S,5S)-4,5-bis(diphenylhydroxymethyl)-2,2-dimethyldioxolane was found to give enantiomeric excesses between 32% and 42% in several examples. The absolute stereo induction in the reaction of benzyl isocyanide, isobutyric aldehyde and benzoic acid with formation of amido ester PhCH2NHCOCH(CHMe2)OCOPh was determined chem. and by X-ray crystallog. This comprises the first asym. Passerini reaction and the first example of a stereochem. induction in an isocyanide-based multicomponent reaction by a chiral Lewis acid. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)).
((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem