Nickel-Catalyzed Asymmetric Reductive Arylalkylation of Unactivated Alkenes was written by Jin, Youxiang;Wang, Chuan. And the article was included in Angewandte Chemie, International Edition in 2019.Recommanded Product: 2-(3-Bromopropyl)-1,3-dioxolane This article mentions the following:
Reported is an asym. reductive dicarbofunctionalization of unactivated alkenes [e.g., 1-bromo-2-(3-methylbut-3-en-1-yl)benzene + 4-bromobutyl acetate → I (69%, 94% ee)]. Under the catalysis of a Ni/BOX system, various aryl bromides, incorporating a pendant olefinic unit, were successfully reacted with an array of primary alkyl bromides in the presence of Zn as a reductant, furnishing a series of benzene-fused cyclic compounds bearing a quaternary stereocenter in high enantioselectivities. Notably, this reaction avoids the use of pregenerated organometallics and demonstrates high tolerance of sensitive functionalities. The preliminary mechanistic investigations reveal that this Ni-catalyzed reaction proceeds as a cascade consisting of migratory insertion and cross-coupling with a nickel(I)-mediated intramol. 5-exo cyclization as the enantiodetermining step. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Recommanded Product: 2-(3-Bromopropyl)-1,3-dioxolane).
2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 2-(3-Bromopropyl)-1,3-dioxolane
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem