Liquid chromatographic separation of enantiomers using a chiral β-cyclodextrin-bonded stationary phase and conventional aqueous-organic mobile phases was written by Hinze, Willie L.;Riehl, Terrence E.;Armstrong, Daniel W.;DeMond, Wade;Alak, Ala;Ward, Tim. And the article was included in Analytical Chemistry in 1985.Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) This article mentions the following:
A chiral stationary phase composed of chem. bonded β-cyclodextrin (β-CD) was used to sep. enantiomers of dansylsulfonamide, β-naphthamide, or β-naphthyl ester derivatives of amino acids, barbiturates, substituted phenylacetic acids, and dioxolanes. The separations are reasonably rationalized in terms of the inclusion process between the enantiomers and β-cyclodextrin and consideration of a 3-point attachment model. The effects of mobile-phase composition, temperature, and flow rate upon the observed enantiomeric selectivity and resolution were critically assessed. A brief prospectus on the usefulness of cyclodextrin chiral stationary phases in high-performance liquid chromatog. enantiomeric separations is presented. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)).
((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem