He, Zhi-Tao’s team published research in Angewandte Chemie, International Edition in 54 | CAS: 503538-69-0

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Formula: C38H24F4O4P2.

He, Zhi-Tao published the artcileEfficient access to bicyclo[4.3.0]nonanes: copper-catalyzed asymmetric silylative cyclization of cyclohexadienone-tethered allenes, Formula: C38H24F4O4P2, the publication is Angewandte Chemie, International Edition (2015), 54(49), 14815-14818, database is CAplus and MEDLINE.

The creation of three consecutive chiral carbon centers in one step is achieved using Cu-catalyzed asym. silylative cyclization of cyclohexadienone-tethered allenes I (1a–x), in reaction with PhMe2SiBpin (2), catalyzed by CuCl/L or CuCl/L2 (L = BINOL phosphoramidite; L2 = BIPHEP, Segphos, Difluorphos, P-Phos, etc.), giving bicyclic enones II (3a–x; X = O, NBoc, CH2; R = Me, Cy, PhCH2, BocNHCH2CH2, alkoxy, CH2:CH, Ph, MeO2CCH2, haloalkyl, aryl); the products 3 were obtained with >90% ee, either as pure diastereomer or with (15-20):1 ratio of (3S,3aR,7aR):(3S,3aS,7aS) diastereomers. The requisite allenyl-tethered cyclohexadienones 1a–r were prepared by oxidative etherification of phenols 4-RC6H4OH with propargyl alc. CHCCH2OH to give cyclohexadienone propargyl ethers HCCCH2O(R)(CH:CH)2CO with subsequent CuBr-catalyzed formaldehyde addition Through regioselective β-silylation of the allene and subsequent enantioselective 1,4-addition to cyclohexadienone, this tandem reaction could afford cis-hydrobenzofuran, cis-hydroindole, and cis-hydroindene frameworks with excellent yields (80-98%) and enantioselectivities (94-98 % ee) bearing vinylsilane and enone substructures. Meanwhile, this mild transformation is generally compatible with a wide range of functional groups, which allows further conversion of the bicyclic products to bridged and tricyclic ring structures.

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Formula: C38H24F4O4P2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem