On October 22, 1982, Hanessian, Stephen; Leblanc, Yves; Lavallee, Pierre published an article.Application In Synthesis of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole The title of the article was Design and reactivity of organic functional groups: the highly crystalline 2-alkoxy-N,N’-diphenyl-1,3,2-diazaphospholanes and their facile conversion into alkyl halides. And the article contained the following:
Reaction of diazaphospholane Me2NR (R = Q) (I) with aliphatic, alicyclic, steroidal, and glycosidal alcs. in PhMe at 85° gave the corresponding 2-alkoxy derivatives in 70-94% yield. These highly crystalline derivatives readily undergo conversion into alkyl halides under mild conditions and with inversion of configuration. E.g., reaction of steroid II (R = β-OH) with I in PhMe at 85° gave 89% II (R = β-OQ) which on treatment with SO2Cl2 in PhMe at 0° gave 80% II (R = α-Cl). The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Application In Synthesis of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
The Article related to alkoxydiazaphospholane preparation halogenation stereospecificity, alc condensation methylaminodiazaphospholane, alkyl halide, steroidal alc condensation diazaphospholane, cyclic alc condensation diazaphospholane, glycoside alc condensation diazaphospholane and other aspects.Application In Synthesis of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem