Identification of agonists for a group of human odorant receptors was written by Gonzalez-Kristeller, Daniela C.;do Nascimento, Joao B. P.;Galante, Pedro A. F.;Malnic, Bettina. And the article was included in Frontiers in Pharmacology in 2015.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:
Olfaction plays a critical role in several aspects of the human life. Odorants are detected by hundreds of odorant receptors (ORs) which belong to the superfamily of G protein-coupled receptors. These receptors are expressed in the olfactory sensory neurons of the nose. The information provided by the activation of different combinations of Ors in the nose is transmitted to the brain, leading to odorant perception and emotional and behavioral responses. There are ∼400 itact human ORs, and to date only a small percentage of these receptors (∼10%) have known agonists. The determination of the specificity of the human Ors will contribute to a better understanding of how odorants are discriminated by the olfactory system. In this work, we aimed to identify human specific ORs, i.e., Ors that are present in humans but absent from other species, and their corresponding agonists. To do this, we first selected 22 OR gene sequences from the human genome with no counter parts in the mouse, rat or dog genomes. Then we use a heterologous expression system to screen a subset of these human Ors against a panel of odorants of biol. relevance, including foodborne aroma volatiles. We found that different types of odorants are able to activate some of these previously uncharacterized human ORs. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).
Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem