Preparation and antimycotic properties of derivatives of 1-phenethylimidazole was written by Godefroi, Erik F.;Heeres, Jan;Van Cutsem, Jan;Janssen, Paul A. J.. And the article was included in Journal of Medicinal Chemistry in 1969.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:
The synthesis of a large number of β-substituted-1-phenethylimidazoles is described. Many appropriately N-substituted-1-(β-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(β-benzyloxyphenethyl)-imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against yeast cells (Candida albicans) and gram-pos. bacteria. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).
2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem