On February 5, 1992, Gilmore, Jeremy; Todd, Alec published a patent.Category: dioxole The title of the patent was Preparation of 5-[1-[(quinolylethenyl)benzyl]indol-7-yloxymethyl]tetrazoles and analogs as leukotriene antagonists. And the patent contained the following:
Title compounds [I; R = CR3R4C6H4YR5; R1 = H, halo, alkyl, alkoxy, etc.; R3, R4 = N, alkyl, (substituted) Ph, etc.; R5 = (substituted) heteroaryl; R6 = H, alkyl; 1 of R7, R8 = XR2 and the other = H; R2 = halo, cyano, CONH2, (protected) acid group, etc.; X = alkylene, oxyalkylene, etc.; Y = OCH2, CH2CH2, CH:CH, etc.] were prepared Thus, I (R1 = R6 = R8 = H) (II; R = H, R7 = OCH2CN) (preparation given) was condensed with quinolylethenylbenzyl chloride QCl and the product treated with Bu3SnN3 to give II (R = Q, R7 = 1H-tetrazol-5-ylmethoxy). I had pKb = 7-11 for dissociation of receptor inhibitor complexes in vitro. The experimental process involved the reaction of Methyl 3-(1,3-dioxolan-2-yl)benzoate(cas: 124038-36-4).Category: dioxole
The Article related to tetrazole quinolylethenylbenzylindolyloxymethyl preparation leukotriene antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: dioxole
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem