New masked δ-lithio carbonyl compounds: preparation and synthetic applications was written by Gil, Juan F.;Ramon, Diego J.;Yus, Miguel. And the article was included in Tetrahedron in 1993.Recommanded Product: 118336-86-0 This article mentions the following:
The reaction of 2-(4-chlorobutyl)-1,3-dioxolanes I (R = H, Et, Ph; R1 = Cl) or 2-(4-chlorobutyl)-2-ethyl-1,3-dithiane with an excess of lithium powder and a catalytic amount of naphthalene (8 mol %) in THF at -78° leads to a solution of the corresponding masked lithium δ-enolates, which react with different electrophiles (water, deuterium oxide, carbonyl compounds, carboxylic acid derivatives, dibenzyl disulfide or benzylideneaniline) to yield the expected products, e.g., I [R = H, R1 = H, D, PhCH(OH), PhCH2S]. In the presence of a catalytic amount of CuBr.Me2S, the intermediate I (R = H, R1 = Li) reacts with cyclohex-2-enone giving the compound I (R = H, R1 = 3-oxocyclohexyl) through a conjugate addition The deprotection of the dioxolane moiety with 2 N HCl gives the expected functionalized carbonyl compounds In situ generated hydroxy aldehydes react with triethylsilane, allyltrimethylsilane, and trimethylsilyl cyanide to give alcs. [e.g., Et2CH(CH2)5OH], dienic alcs. [e.g., Me2C:CH(CH2)3CH(OH)CH2CH:CH2], and cyanooxepanes II (R2 = H, R3 = Ph; R2 = R3 = Me, Et; R2R3 = (CH2)5]. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Recommanded Product: 118336-86-0).
2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 118336-86-0
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem