On May 3, 2022, Gao, Yangguang; Deng, Changxuan; Yang, Jie; Lu, Wangting published a patent.Application of 38838-06-1 The title of the patent was Preparation of natural alpha-glucosidase inhibitor Penasulfate A. And the patent contained the following:
The present invention relates to preparation of natural α-glucosidase inhibitor Penasulfate A. In particular, the preparation method comprises of following steps: (1) obtaining compound 6, compound 7 and compound 3 resp.; subjecting compound 6 and 7 to Suzuki coupling reaction to obtain compound 4; the compound 4 and compound 3 are subjected to a first olefin metathesis reaction under the action of a first preset catalyst to obtain compound 16; the compound 16 is further subjected to a first hydrogenation reduction reaction to obtain compound 2 and a methanol solution of acetyl chloride; deprotection reaction of the compound 2 and the methanol solution of acetyl chloride, followed by sulfonylation and pH adjustment, to obtain a natural α-glucosidase inhibitor Penasulfate A that can be produced on a large scale. The inventive method requires only need ten steps, the steps and time required for the reaction are greatly shortened, and the large-scale production of Penasulfate A can be realized. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Application of 38838-06-1
The Article related to penasulfate a synthesis alpha glucosidase inhibitor, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Application of 38838-06-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem