On February 3, 2005, Fryszman, Olga M.; Lang, Hengyuan; Lan, Jiong; Chang, Edcon; Fang, Yunfeng published a patent.Application In Synthesis of Methyl 3-(1,3-dioxolan-2-yl)benzoate The title of the patent was Preparation of 5-membered heterocycles, in particular pyrazoles and imidazoles, as p38 kinase inhibitors. And the patent contained the following:
Title compounds I of [wherein R1 = H, acyl, P(:O)(OH)2; R2 = H, halo, (un)substituted alkyl, alkylthio, alkylsulfinyl, etc.; G = hetero/aryl, aralkyl, cycloalkyl, etc.; B = hetero/aryl; A = 5-membered ring containing one or two heteroatoms in the ring; D = CONH2 and derivatives, (un)substituted heteroaryl; R5 = H, halo, halo/thio/alkyl, OH and derivatives, alkyl/amino, etc.; R6 = H, halo, alkyl, alkoxy; and their pharmaceutically acceptable derivatives] were prepared as p38 kinase, including p38α and p38β kinase, inhibitors. Thus, reacting 3-hydrazino-N-methoxy-4-methylbenzamide with NaNO2 in the presence of SnCl2, and cyclization of the hydrazine with 2-(3-iodobenzoyl)-3-phenylaminoacrylonitrile gave II. Selected I displayed IC50 values <1 μM in a p38α kinase inhibition assay. I are useful for the treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, e.g. inflammatory disease, autoimmune disease, etc. The experimental process involved the reaction of Methyl 3-(1,3-dioxolan-2-yl)benzoate(cas: 124038-36-4).Application In Synthesis of Methyl 3-(1,3-dioxolan-2-yl)benzoate
The Article related to imidazole preparation p38 kinase inhibitor inflammation immunomodulator, antiinflammatory agent pyrazole preparation p38 kinase inhibition autoimmune disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application In Synthesis of Methyl 3-(1,3-dioxolan-2-yl)benzoate
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem