Triazoloamides as potent γ-secretase modulators with reduced hERG liability was written by Fischer, Christian;Zultanski, Susan L.;Zhou, Hua;Methot, Joey L.;Shah, Sanjiv;Nuthall, Hugh;Hughes, Bethany L.;Smotrov, Nadja;Hill, Armetta;Szewczak, Alexander A.;Moxham, Christopher M.;Bays, Nathan;Middleton, Richard E.;Munoz, Benito;Shearman, Mark S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Electric Literature of C7H5F2NO2 This article mentions the following:
Synthesis and SAR studies of novel aryl triazoles as gamma secretase modulators (GSMs) are presented in this communication. Starting from aryl triazole leads, optimization studies were continued and the series progressed towards novel amides and lactams. Triazole I was identified as the most potent analog in this series, displaying single-digit nanomolar Aβ42 IC50 in cell-based assays and reduced affinity for the hERG channel. In the experiment, the researchers used many compounds, for example, 2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0Electric Literature of C7H5F2NO2).
2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C7H5F2NO2
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem