The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: H-Trp-OMe.HCl(SMILESS: N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl,cas:7524-52-9) is researched.Electric Literature of C2H7OP. The article 《Chemoselective peptide backbone diversification and bioorthogonal ligation by ruthenium-catalyzed C-H activation/annulation》 in relation to this compound, is published in Advanced Synthesis & Catalysis. Let’s take a look at the latest research on this compound (cas:7524-52-9).
The field of peptide derivatization by metal-catalyzed C-H activation has been mostly directed to modify the side chains, but poor attention has been given to the peptide backbone. Here we report a ruthenium-catalyzed C-H activation/annulation process that can chemoselectively modify the peptide backbone producing functionalized isoquinolone scaffolds with high regioselectivity in a rapid and step-economical manner. This strategy is characterized by racemization-free conditions and the production of fluorescent peptides, and peptide conjugates to drugs, natural products and other peptide fragments, providing a chem. approach for the construction of novel peptide-pharmacophore conjugates. Mechanistic studies suggest that amide bonds of peptide backbone act as the bidentate directing group to promote the C-H activation/annulation process. This report provides an unprecedented example of peptide backbone diversification and bioorthogonal ligation exploiting the power of ruthenium-catalyzed C-H activation.
From this literature《Chemoselective peptide backbone diversification and bioorthogonal ligation by ruthenium-catalyzed C-H activation/annulation》,we know some information about this compound(7524-52-9)Quality Control of H-Trp-OMe.HCl, but this is not all information, there are many literatures related to this compound(7524-52-9).
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem