Winterton, Sarah E.; Capota, Emanuela; Wang, Xiaoyu; Chen, Hong; Mallipeddi, Prema L.; Williams, Noelle S.; Posner, Bruce A.; Nijhawan, Deepak; Ready, Joseph M. published an article about the compound: 5-Chloropyridin-3-amine( cas:22353-34-0,SMILESS:NC1=CC(=CN=C1)Cl ).Recommanded Product: 5-Chloropyridin-3-amine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:22353-34-0) through the article.
Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. However, systemically active SCD inhibitors result in skin toxicity, which presents an obstacle to their development. We recently described a series of oxalic acid diamides that are converted into active SCD inhibitors within a subset of cancers by CYP4F11-mediated metabolism Herein, we describe the optimization of the oxalic acid diamides and related N-acyl ureas and an anal. of the structure-activity relationships related to metabolic activation and SCD inhibition.
There is still a lot of research devoted to this compound(SMILES：NC1=CC(=CN=C1)Cl)Recommanded Product: 5-Chloropyridin-3-amine, and with the development of science, more effects of this compound(22353-34-0) can be discovered.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem