With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80841-78-7,4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one,as a common compound, the synthetic route is as follows.,80841-78-7
Example 1-5 (0330) (0331) A mixture of BIC (0.6 g, 0.83 mmol), potassium iodide (0.069 g, 0.41 mmol), OXC (0.245 g, 1.65 mmol) and methyl ethyl ketone (9.0 mL, 15 vol) was stirred at 50 C. for 20 hr. The reaction mixture was filtered, the filtrate was concentrated under reduced pressure, and the obtained concentrated residue was purified by silica gel column chromatography (20-22% ethyl acetate/hexane) to give TOLM (650 mg, yield 84.4%). (0332) Mass: 801 [M+H]+, 824 [M+Na]+.
The synthetic route of 80841-78-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; API CORPORATION; Seki, Masahiko; US2015/239854; (2015); A1;,
1,3-Benzodioxole – Wikipedia
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