Downstream synthetic route of 144690-92-6

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Example 8; Olmesartan medoxomil (V); Water (10 g) was added to a solution of the starting substance (III; 20 g) in acetone (50 ml), and the mixture was heated to a mild boil for 14 h. After the reaction was completed, the mixture was cooled to 0 0C, and the formed trityl alcohol was sucked off. After concentration, a crude product was obtained, which was extracted with ethyl acetate (70 ml). After evaporating the extract and crystallizing from acetone, 10.6 g (76 %) of the product with an HPLC purity of 97.0 % was obtained. Recrystallization from ethyl methyl ketone gave 10.2 g (73 %) of the product with an HPLC purity of 99.3 %; m.p. 175-177 C.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 144690-92-6.C48H44N6O6

Reference£º
Patent; ZENTIVA, A.S.; WO2007/48361; (2007); A1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem