Downey, A. Michael; Pohl, Radek; Roithova, Jana; Hocek, Michal published an article in 2017, the title of the article was Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Mono-protected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism.Recommanded Product: 38838-06-1 And the article contains the following content:
Simplifying access to synthetic nucleosides is of interest due to their widespread use as biochem. or anticancer and antiviral agents. Herein, a direct stereoselective method to access an expansive range of both natural and synthetic nucleosides, e.g. I, up to a gram scale, through direct glycosylation of nucleobases with 5-O-tritylribose and other C5-modified ribose derivatives, is discussed in detail. The reaction proceeds through nucleophilic epoxide ring opening of an in situ formed 1,2-anhydrosugar (termed “anhydrose”) under modified Mitsunobu reaction conditions. The scope of the reaction in the synthesis of diverse nucleosides and other 1-substituted riboside derivatives is described. In addition, a mechanistic insight into the formation of this key glycosyl donor intermediate is provided. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Recommanded Product: 38838-06-1
The Article related to mitsunobu nucleoside riboside glycosylation nucleobase preparation, nucleoside anticancer antiviral glycosylation nucleophilic epoxide ring opening, epoxides, glycosylation, nucleosides, riboses, synthesis design and other aspects.Recommanded Product: 38838-06-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem