The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: H-Trp-OMe.HCl( cas:7524-52-9 ) is researched.Product Details of 7524-52-9.Stanfield, Joshua Kyle; Omura, Keita; Matsumoto, Ayaka; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito; Shoji, Osami published the article 《Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain》 about this compound( cas:7524-52-9 ) in Angewandte Chemie, International Edition. Keywords: crystal structure crystallization microcrystn CYP102A1 P450BM3 heme domain metalloporphyrin; crystal growth; cytochromes; decoy molecules; enzyme models; protein structures. Let’s learn more about this compound (cas:7524-52-9).
Despite CYP102A1 (P450BM3) representing one of the most extensively researched metalloenzymes, crystallization of its heme domain upon modification can be a challenge. Crystal structures are indispensable for the efficient structure-based design of P450BM3 as a biocatalyst. The abietane diterpenoid derivative N-abietoyl-L-tryptophan (AbiATrp) is an outstanding crystallization accelerator for the wild-type P450BM3 heme domain, with visible crystals forming within 2 h and diffracting to a near-at. resolution of 1.22 Å. Using these crystals as seeds in a cross-microseeding approach, an assortment of P450BM3 heme domain crystal structures, containing previously uncrystallisable decoy mols. and diverse artificial metalloporphyrins binding various ligand mols., as well as heavily tagged heme-domain variants, could be determined Some of the structures reported herein could be used as models of different stages of the P450BM3 catalytic cycle.
After consulting a lot of data, we found that this compound(7524-52-9)Product Details of 7524-52-9 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem