The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide( cas:707-61-9 ) is researched.Quality Control of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide.Marsden, Stephen P.; McGonagle, Alison E.; McKeever-Abbas, Ben published the article 《Catalytic aza-Wittig Cyclizations for Heteroaromatic Synthesis》 about this compound( cas:707-61-9 ) in Organic Letters. Keywords: phenanthridine benzoxazole preparation; iminophosphorane formation aza Wittig cyclization isocyanate phospholene oxide catalyst. Let’s learn more about this compound (cas:707-61-9).
The first examples of heterocycle synthesis by iminophosphorane formation/intramol. aza-Wittig cyclizations that are catalytic in the organophosphorus component are reported. The reaction has been demonstrated in the synthesis of both azine (phenanthridine) and azole (benzoxazole) heterocycles. E.g., in presence of phospholene oxide I, reaction of isocyanate 2-OCNC6H4C6H4CO2Me-2, formed from acyl azide 2-N3COC6H4C6H4CO2Me-2 by Curtius rearrangement, gave 71% phenanthridine II. Catalyst loadings down to 1 mol % have been used with little or no loss in reaction efficiency. The intimate involvement of the phosphine oxide in the catalytic cycle has been verified by in situ IR spectroscopy.
From this literature《Catalytic aza-Wittig Cyclizations for Heteroaromatic Synthesis》,we know some information about this compound(707-61-9)Quality Control of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, but this is not all information, there are many literatures related to this compound(707-61-9).
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem