Quality Control of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Synthesis of some 1-aryl-2,3-dibromophospholanes as novel anti-cancer agents. Author is Yamada, Manabu; Asai, Kazuhide; Yamashita, Junko; Suyama, Takuya; Niimi, Taishi; Maddali, Kasthuraiah; Fujie, Michio; Nakamura, Satoki; Kimura, Motohiko; Tanaka, Yasutaka; Toda, Mitsuo; Yamashita, Mitsuji.
Novel phosphorus heterocyclic compounds, 3-methyl-1-(3-bromophenyl as well as some 3-substituted phenyl)-2-phospholene 1-oxides, were synthesized from 1-phenyl-2-phospholene 1-oxide via 3-methyl-1-(3-nitrophenyl)-2-phospholene 1-oxide. 1-(4-Bromophenyl)-2-phospholene was prepared by Grignard coupling reaction of 1-chloro-3-methyl-2-phospholene 1-oxide with 4-bromophenylmagnesium bromide. 2,3-Dibromo-3-methyl-1-arylphospholane 1-oxides were prepared by the addition reaction of bromine to the C=C double bond of 2-phospholenes. The substituent effect of the Ph group of the 1-aryl-phospholanes on the observed anti-proliferative effect against U937 leukemia cell lines evaluated by MTT in vitro methods showed that 2,3-dibromo-3-methyl-1-(4-bromophenyl)phospholane was the most active among 1-arylphospholanes. These novel dibromophosphorus heterocyclic derivatives exhibit much higher anticancer activity than Gleevec (mol. targeting chemotherapeutic agent) against U937 cells.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem