The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: H-Trp-OMe.HCl( cas:7524-52-9 ) is researched.HPLC of Formula: 7524-52-9.Le Roch, Adrien; Hebert, Martin; Gagnon, Alexandre published the article 《Copper-promoted O-arylation of the phenol side chain of tyrosine using triarylbismuthines》 about this compound( cas:7524-52-9 ) in European Journal of Organic Chemistry. Keywords: tyrosine peptide arylated synthesis amino acid racemization; peptide coupling tyrosine arylation copper catalyst triarylbismuthine oxygen. Let’s learn more about this compound (cas:7524-52-9).
A general method for the O-arylation of the side chain of tyrosine using triarylbismuth reagents is reported. The reaction is mediated by copper diacetate, operates at 50°C under oxygen in dichloromethane in the presence of pyridine, shows excellent functional group compatibility, and retains the integrity of the stereogenic center. The protocol was used to arylate the tyrosine residue of dipeptides and tripeptides.
There is still a lot of research devoted to this compound(SMILES：N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl)HPLC of Formula: 7524-52-9, and with the development of science, more effects of this compound(7524-52-9) can be discovered.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem