The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ) is researched.Application of 4360-63-8.Li, Yaoqi; Sun, Zhihua published the article 《Synthesis of lesinurad via a multicomponent reaction with isocyanides and disulfides》 about this compound( cas:4360-63-8 ) in Heterocycles. Keywords: Lesinurad preparation. Let’s learn more about this compound (cas:4360-63-8).
An efficient synthesis of Lesinurad I, a selective uric acid reabsorption inhibitor was developed via reaction starting from 4-cyclopropylnaphthalen-1-amine hydrochloride. The route to synthesis of compound I avoided the use of thiophosgene and the formation of thiols. The key reaction in this synthesis was construction of the 1,2,4-triazole ring in 72% yield. Compound I is obtained in 45% yield over 5 steps.
There is still a lot of research devoted to this compound(SMILES：BrCC1OCCO1)Application of 4360-63-8, and with the development of science, more effects of this compound(4360-63-8) can be discovered.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem