Electric Literature of C12H15ClN2O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Selective photoredox trifluoromethylation of tryptophan-containing peptides. Author is Ding, Bo; Weng, Yue; Liu, Yunqing; Song, Chunlan; Yin, Le; Yuan, Jiafan; Ren, Yanrui; Lei, Aiwen; Chiang, Chien-Wei.
For application in drug discovery and biomedicine, it is crucial to develop new biocompatible methods to modify polypeptides. Herein, a visible-light-induced photoredox trifluoromethylation of tryptophan-containing peptides is reported. Under a mild, biocompatible, and straightforward condition, this strategy could incorporate the trifluoromethyl group into tryptophan residue with excellent chemo- and site-selectivity. The use of lower photocatalyst loading in 2 mol-% and cheap CF3SO2Na salt represents a great catalytic activity and economic CF3 source. This direct trifluoromethylation strategy allows the ready study of fluorinated peptides exploiting 19F-NMR. Addnl., the development of this protocol enables the study of biochem. systems and potentially modulates the function of biomols. Nt effect Careful mechanistic studies (Stern-Volmer fluorescence quenching, EPR, and radical inhibition/trapping experiments) indicate that the reaction would proceed with a radical-radical cross-coupling procedure.
There is still a lot of research devoted to this compound(SMILES：N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl)Electric Literature of C12H15ClN2O2, and with the development of science, more effects of this compound(7524-52-9) can be discovered.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem