So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mas-Rosello, Josep; Smejkal, Tomas; Cramer, Nicolai researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).HPLC of Formula: 4360-63-8.They published the article 《Iridium-catalyzed acid-assisted asymmetric hydrogenation of oximes to hydroxylamines》 about this compound( cas:4360-63-8 ) in Science (Washington, DC, United States). Keywords: iridium catalyzed acid assisted asym hydrogenation oxime hydroxylamine. We’ll tell you more about this compound (cas:4360-63-8).
Asym. hydrogenations are among the most practical methods for the synthesis of chiral building blocks at industrial scale. The selective reduction of an oxime to the corresponding chiral hydroxylamine derivative remains a challenging variant because of undesired cleavage of the weak nitrogen-oxygen bond. We report a robust cyclometalated iridium(III) complex bearing a chiral cyclopentadienyl ligand as an efficient catalyst for this reaction operating under highly acidic conditions. Valuable N-alkoxy amines can be accessed at room temperature with nondetected overredn. of the N-O bond [e.g., (E)-I → (S)-II (97%, 97.5:2.5 er)]. Catalyst turnover numbers up to 4000 and enantiomeric ratios up to 98:2 are observed The findings serve as a blueprint for the development of metal-catalyzed enantioselective hydrogenations of challenging substrates.
Although many compounds look similar to this compound(4360-63-8)HPLC of Formula: 4360-63-8, numerous studies have shown that this compound(SMILES:BrCC1OCCO1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem