Category: Dioxole

Liu, Bin-bin published the artcileOdorless thioacetalization reaction of acetals, Computed Properties of 177-10-6, the publication is Liaoning Huagong (2014), 43(9), 1112-1113, database is CAplus.

Using 2-(1,3-dithian-2-ylidene)-3-oxobutanoic acid as odorless thiol equivalent, an efficient and odorless transthioacetalization of acetals has been developed in the presence of MeCOCl in MeOH at room temperature This transthioacetalization is characterized by mild reaction conditions, simple procedure and good yield. It is noteworthy that odor of thiols can not be perceived during the reaction.

Liaoning Huagong published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Computed Properties of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tan, Yu Jia published the artcileAmide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility, Related Products of dioxole, the publication is ACS Medicinal Chemistry Letters (2021), 12(5), 704-712, database is CAplus and MEDLINE.

Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here, it was found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (MIC_90Mtb 0.13μM, MBC_99.9Mtb 0.63μM), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.

ACS Medicinal Chemistry Letters published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C18H17NO8, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

He, Cheng-Yu published the artcileCopper-Catalyzed Asymmetric Borylative Cyclization of Cyclohexadienone-Containing 1,6-Dienes, HPLC of Formula: 503538-69-0, the publication is Advanced Synthesis & Catalysis (2020), 362(4), 765-770, database is CAplus.

Due to the low reactivity of 1,6-dienes and the challenge of selectively differentiating such two olefins, the development of metal-catalyzed asym. cyclization of 1,6-dienes remains largely underdeveloped. Herein, the authors describe the 1st Cu(I)-catalyzed asym. borylative cyclization of cyclohexadienone-tethered terminal alkenes (1,6-dienes) via a tandem process: the regioselective borocupration of the electron-rich terminal alkene and subsequent conjugate addition of stereospecific secondary alkyl-Cu(I) to the electron-deficient cyclohexadienone, affording enantioenriched bicyclic skeletons bearing three contiguous stereocenters in all cis-form. Meanwhile, this mild catalytic protocol is generally compatible with a wide range of functional groups, which allows further facile conversion of the cyclization products.

Advanced Synthesis & Catalysis published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, HPLC of Formula: 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Wang, Rui published the artcileCrystal structure, thermal decomposition mechanism and catalytic performance of hexaaquaaluminum methanesulfonate, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Journal of Coordination Chemistry (2017), 70(8), 1327-1338, database is CAplus.

Hexaaquaaluminum methanesulfonate crystals, [Al(H₂O)₆][CH₃SO₃]₃ (1) were synthesized by a hydrothermal reaction of Al(OH)₃ with methanesulfonic acid. Single-crystal diffraction determination revealed that Al³⁺ was coordinated by six water mols. in octahedral geometry, while the CH₃SO₃^– anion connected with Al³⁺ through coordinated water mols. by hydrogen bonds. The six-coordinate environment of Al was also determined by ²⁷Al MAS NMR measurement. TGA and FTIR spectroscopy showed that the decomposition intermediate at 265-365° was Al₂(μ-OH)(CH₃SO₃)₅ (2) and the final product was amorphous Al₂O₃ residue with ∼0.8% SO₃ at 520-800°. A pure phase of [Al(H₂O)₆][CH₃SO₃]₃ was confirmed by powder x-ray diffraction anal. Esterification of n-butyric acid with n-butanol and ketalization of cyclohexanone with glycol catalyzed by [Al(H₂O)₆][CH₃SO₃]₃ and Al₂(μ-OH)(CH₃SO₃)₅, resp., proceeded in 100% yield by continuously removing the produced water. In the case of tetrahydropyranylation of n-butanol at room temperature in dichloromethane, the catalytic activity of [Al(H₂O)₆][CH₃SO₃]₃ was much lower than that of Al₂(μ-OH)(CH₃SO₃)₅. Furthermore, both [Al(H₂O)₆][CH₃SO₃]₃ precursor and Al₂(μ-OH)(CH₃SO₃)₅ catalysts could be recycled.

Journal of Coordination Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H6BF3O3, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Islam, Tofazzal Md. published the artcileHost-specific plant signal and G-protein activator, mastoparan, trigger differentiation of zoospores of the phytopathogenic oomycete Aphanomyces cochlioides, COA of Formula: C16H10O5, the publication is Plant and Soil (2003), 255(1), 131-142, database is CAplus.

We found that a gradient of a host-specific attractant, cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone) isolated from the roots of spinach triggered encystment followed by germination of zoospores of Aphanomyces cochlioides at a concentration less than micromolar order. This compound did not affect the growth and reproduction of this phytopathogen up to 10^-6 M concentration in the culture medium. We also observed that mastoparan, an activator of heterotrimeric G-protein could inhibit the motility of zoospores and then strikingly effect encystment followed by 60-80% germination of cysts. Concomitant application of cochliophilin A and mastoparan showed stronger encystment followed by 100% germination of cysts. In addition, we have observed that chems. interfering with phospholipase C activity (neomycin) and Ca²⁺ influx/release (EGTA and loperamide) suppress cochliophilin A or mastoparan induced encystment and germination. These results suggest that G-protein mediated signal transduction mechanism may be involved in the differentiation of the A. cochlioides zoospores. This is the first report on the differentiation of oomycete zoospores initiated by a host-specific plant signal or a G-protein activator.

Plant and Soil published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, COA of Formula: C16H10O5.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Pouretedal, Hamid Reza published the artcileA simple method for predicting the gas-chromatographic retention indices of phenolic derivatives, Formula: C11H14O4, the publication is Journal of the Iranian Chemical Society, database is CAplus.

A simple approach is proposed to predict the gas-chromatog. retention indexes in nonpolar columns for a wide range of phenolic derivatives, through their mol. structures and independent of temperature data and active phase of column. The new model is based on the number of atoms and some structural moieties which depend on intra- and intermol. interactions. The present method can be easily applied for many kinds of phenolic compounds containing different substituents without using special computer codes, which need expert users. A big pool of the exptl. data (335 compounds) of retention indexes is used to construct the new model (80% for training set and 20% for test set). Different statistical parameters including the coefficient of determination, R2 (= 0.9482), root mean squared error, RMSE (= 89.01), and mean absolute percent error, MAPE (= 4.494), are used to investigate the reliability of the model, through both internal and external validation techniques.

Journal of the Iranian Chemical Society published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Formula: C11H14O4.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Zhao, Shen published the artcileAcetalization of aldehydes and ketones over H₄[SiW₁₂O₄₀] and H₄[SiW₁₂O₄₀]/SiO₂, Formula: C8H14O2, the publication is Catalysis Science & Technology (2014), 4(8), 2618-2625, database is CAplus.

H₄[SiW₁₂O₄₀] (H-SiW₁₂) is demonstrated to be able to efficiently catalyze the acetalization of aldehydes and ketones with ethylene glycol and 1,3-propanediol. Nevertheless, the possible leaching and the recycling of H-SiW₁₂ are two major disadvantages that largely restrict its further application in industry. Moreover, H₄[SiW₁₂O₄₀] tends to deactivate strong proton sites due to the small surface area of 10 m² g^-1. Due to interactions with surface silanol groups, the proton sites of polyoxometalates (POMs) on SiO₂ are less susceptible to deactivation. As such, immobilization of H₄[SiW₁₂O₄₀] onto SiO₂ leads to the heterogeneous catalyst H₄[SiW₁₂O₄₀]/SiO₂ (H-SiW₁₂/SiO₂), which can catalyze the acetalization of aldehydes and ketones with ethylene glycol and 1,3-propanediol selectively and efficiently without the need of a drying agent. The acetalization process can proceed smoothly at a relatively low temperature under solvent-free conditions. The catalyst of H₄[SiW₁₂O₄₀]/SiO₂ can be recycled at least ten times without an obvious decrease in its catalytic activity. As far as we know, the TONs of the H-SiW₁₂/SiO₂-catalyzed acetalization of cyclohexanone with ethylene glycol, and benzaldehyde with 1,3-propanediol are the highest reported so far.

Catalysis Science & Technology published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C18H28N2O7, Formula: C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Jadhav, Sumit V. published the artcileNanosized sulfated zinc ferrite as catalyst for the synthesis of nopol and other fine chemicals, SDS of cas: 177-10-6, the publication is Catalysis Today (2012), 198(1), 98-105, database is CAplus.

A nanosized highly ordered mesoporous zinc ferrite (ZnFe₂O₄; ZF) was synthesized via co-precipitation method, further sulfated with ammonium sulfate solution to obtain sulfated ZF (SZF) and have been used for the synthesis of nopol by Prins condensation of β-pinene and paraformaldehyde. The NH₃-TPD and pyridine sorption DRIFT-IR studies revealed the significant enhancement in Lewis acidic sites of the zinc ferrite on sulfatation. The influence of various reaction parameters such as reaction temperature, effect of substrate stoichiometry and catalyst loading has been investigated. It gave 70% conversion of β-pinene with 88% selectivity to nopol. The spent catalyst was regenerated and reused successfully up to four cycles with slight loss in catalytic activity. The nanosized SZF catalyst was found to be highly active towards several other com. important acid catalyzed reactions such as isomerization, acetalization and aldol condensation.

Catalysis Today published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, SDS of cas: 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Kwon, Ki-Dong published the artcileCharacterization of emissions composition for selected household products available in Korea, HPLC of Formula: 1193-11-9, the publication is Journal of Hazardous Materials (2007), 148(1-2), 192-198, database is CAplus and MEDLINE.

This study examined the emission composition for 59 household products currently sold in Korea, using a headspace anal. The chem. composition and concentrations of total volatile organic compounds (VOCs) broadly varied along with products, even within the same product category. Up to 1-17 organics were detected in the headspace gas phase of any one of the products. The chem. composition of certain household products determined in the current study was different from that of other studies from other countries. Between 4 and 37 compounds were detected in the headspace gas phase of each product class. Several compounds were identified in >1 product class. Of the 59 household products analyzed, 58 emitted ≥1 of the 72 compounds at chromatog. peak areas above 10⁴. There were 11 analytes which occurred with a frequency of >10%: Limonene (44.2%), ethanol (30.5%), acetone (18.6%), α-pinene (18.6%), o,m,p-xylenes (18.6%), decane (17.0%), toluene (17.0%), β-myrcene (11.9%), ammonia (10.2%), ethylbenzene (10.2%), and hexane (10.2%).

Journal of Hazardous Materials published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, HPLC of Formula: 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Yin, Liang published the artcileA Facile Pathway to Enantiomerically Enriched 3-Hydroxy-2-Oxindoles: Asymmetric Intramolecular Arylation of α-Keto Amides Catalyzed by a Palladium-DifluorPhos Complex, Recommanded Product: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, the publication is Angewandte Chemie, International Edition (2011), 50(33), 7620-7623, S7620/1-S7620/90, database is CAplus and MEDLINE.

The first catalytic, enantioselective intramol. aryl-transfer reaction of aryl triflates to ketones has been developed, providing 3-hydroxy-2-oxindoles, e.g., I, from α-keto amides, e.g., II, in 82-99% ee. Initial extension of the methodol. to the synthesis of 4-hydroxydihydroquinolin-2-ones is also explored. This method features overall practicality, including substrate stability and accessibility (protecting-group free) plus no need for the use of stoichiometric amounts of metals.

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C7H13ClNNaO5S, Recommanded Product: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem