Category: Dioxole

Yang, Shuijin et al. published their research in Xiangliao Xiangjing Huazhuangpin in 2006 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Synthetic Route of C8H14O4

Catalytic synthesis of acetals and ketals with iodine was written by Yang, Shuijin;Tong, Wenlong. And the article was included in Xiangliao Xiangjing Huazhuangpin in 2006.Synthetic Route of C8H14O4 The following contents are mentioned in the article:

Catalytic activities of Iodine in synthesizing 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane, cyclohexanone ethylene ketal, cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane, 4-methyl-2-propyl-1,3-dioxolane were reported. It was demonstrated that Iodine was an excellent catalyst. Various factors concerned in these reactions were investigated. The optimum conditions were found, that was, the molar ratio of aldehyde/ketone to glycol was 1/1.3, the mass ratio of the catalyst used to the reactant s was 0.4%, and the reaction time was 40-60 min. Under these conditions, the yield of 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane was 63.8%, and 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane was 70.7%, the yield of cyclohexanone ethylene ketal was 85.9%, and cyclohexanone 1,2-propanediol ketal was 88.8%, the yield of butanone ethylene ketal was 45.2%, and butanone 1,2-propanediol ketal was 86.9%, the yield of 2-phenyl-1,3-dioxolane was 80.3%, and 4-methyl-2-phenyl-1,3-dioxolane was 86.3%, the yield of 2-propyl-1,3-dioxolane was 83.6%, and 4-methyl-2-propyl-1,3-dioxolane was 91.2%. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Synthetic Route of C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Synthetic Route of C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Goodreid, Jordan D. et al. published their research in Journal of Organic Chemistry in 2014 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 6413-10-1

Amidation Reactions from the Direct Coupling of Metal Carboxylate Salts with Amines was written by Goodreid, Jordan D.;Duspara, Petar A.;Bosch, Caroline;Batey, Robert A.. And the article was included in Journal of Organic Chemistry in 2014.Related Products of 6413-10-1 The following contents are mentioned in the article:

A general method for the synthesis of amides involving the direct coupling of alkali metal carboxylate salts with amines is described. Amidation of a wide variety of carboxylate salts with either free amines or their ammonium hydrochloride salts can be achieved using HBTU as a coupling agent in combination with Huenig’s base. The reaction is highly efficient and is generally complete in as little as 1-2 h, giving the products in good to excellent yields. The protocol is valuable for the coupling of carboxylates for which the corresponding carboxylic acids or acyl chlorides are unstable, less conveniently manipulated/isolated, or are not com. available. For example, the coupling of amines and α-amino acids with lithium 5-bromo-1H-pyrrole-2-carboxylate, whose corresponding acid that is prone to decarboxylation, allowed for the synthesis of 5-bromo-1H-pyrrole-2-carboxamides, which are analogs of the pyrrole-2-aminoimidazole marine alkaloids. The protocol can be combined with other reactions in a sequenced fashion, as exemplified by the synthesis of acetylenic amides, in a one-pot procedure, via the coupling of a lithium carboxylate salt formed initially by the addition of carbon dioxide to a lithiated terminal alkyne. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Related Products of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Liu, Qingyin et al. published their research in Bioorganic Chemistry in 2020 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Total synthesis and anti-inflammatory evaluation of violacin A and its analogues was written by Liu, Qingyin;Mu, Yu;An, Qi;Xun, Jiali;Ma, Jian;Wu, Wenxi;Xu, Minjuan;Xu, Jun;Han, Li;Huang, Xueshi. And the article was included in Bioorganic Chemistry in 2020.Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

A concise total synthesis of an exceedingly potent anti-inflammatory agent violacin A (I) as well as the preparation of thirty analogs of this lead from com. available orcinol are described. Highlights of our synthetic efforts involve Friedel-Crafts acylation, the regioselective etherification and esterification of phenolic hydroxyl groups, and Baker-Venkataraman rearrangement to form basic skeleton of violacin A. The deprotection reaction with Pd-catalytic was involved to avoid the elimination of the hemiacetal hydroxyl at C2. In addition, all synthetic compounds were screened for anti-inflammatory activity against nitric oxide (NO) production using lipopolysaccharide (LPS)-induced Raw264.7 cells. A range of violacin A derivatives II – V [R = Me, (un)substituted benzyl] exhibited stronger anti-inflammatory effect than that of violacin A. Notably, halogeno-benzyloxy substituent at C-7 were favorable for anti-inflammatory activities of violacin A derivatives Addnl., Western blot results indicated halogeno-benzyloxy derivatives inhibited pro-inflammatory cytokines releases correlated with the suppression of NF-κB signaling pathway. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Zhang, Fu-min et al. published their research in Gaoxiao Huaxue Gongcheng Xuebao in 2006 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C8H14O4

Catalytic behavior of SBA-15 supported heteropoly compounds in synthesis of fructone was written by Zhang, Fu-min;Yuan, Chao-shu;Wang, Jun. And the article was included in Gaoxiao Huaxue Gongcheng Xuebao in 2006.Formula: C8H14O4 The following contents are mentioned in the article:

Catalysts of 12-tungstophosphoric acid (PW), cesium salt of PW and potassium salt of PW supported on mesoporous silica SBA-15 with different loadings were prepared by impregnation, resp. Their catalytic behaviors were investigated via the acetalization of Et acetoacetate with ethylene glycol to synthesize fructone. The phys. and chem. properties of the catalysts prepared were characterized by N2 adsorption, Hammett indicator and FT-IR. The catalytic stability of the catalysts was evaluated by water treatment test, in which the concentration of the heteropoly compound leaking into the water was measured by UV-visual spectrophotometer. It is found that the catalysts have no activity in the synthesis of fructone when the loading of PW on SBA-15 is lower than 30% and the loading of Cs salt or K salt of PW on SBA-15 is lower than 20%. During repeatedly using, the deactivation of the catalysts prepared is closely associated with the leakage of active heteropoly species into the polar solvent. Since in the polar reaction system, the cesium salts of PW are water-tolerant, it causes the catalyst of supported cesium salts of PW on SBA-15 has higher catalytic stability. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Formula: C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Lu, Baolan’s team published research in Jingxi Shiyou Huagong Jinzhan in 12 | CAS: 177-10-6

Jingxi Shiyou Huagong Jinzhan published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Formula: C8H14O2.

Lu, Baolan published the artcileCatalytic synthesis of cyclohexanone ethylene ketal over phosphotungstic acid/silica gel, Formula: C8H14O2, the publication is Jingxi Shiyou Huagong Jinzhan (2011), 12(12), 50-52, database is CAplus.

Cyclohexanone ethylene ketal I was synthesized with cyclohexanone and glycol as the materials, and the catalytic activity of phosphotungstic acid/silica gel catalyst in ketol reaction was studied. According to the results, phosphotungstic acid/silica gel (SG) is a good catalyst for the synthesis of cyclohexanone ethylene ketal. The optimum synthesis conditions were identified: n (cyclohexanone):n (glycol) = 1:1.4, amount of water-carrying agent (i.e. cyclohexane): 8 mL, reaction time: 30 min. The yield of cyclohexanone ethylene ketal can reach 76.4% at such conditions.

Jingxi Shiyou Huagong Jinzhan published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Formula: C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Zhu, Haotian’s team published research in Yingyong Huaxue in 32 | CAS: 177-10-6

Yingyong Huaxue published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C17H14O5, COA of Formula: C8H14O2.

Zhu, Haotian published the artcileSynthesis, crystal structure and catalytic activity of a Dawson-type tungstophosphate decorated by copper complexes, COA of Formula: C8H14O2, the publication is Yingyong Huaxue (2015), 32(4), 433-441, database is CAplus.

An inorganic-organic hybrid compound [Cu(H2biim)2(H2O)][{Cu(H2biim)2}2(P2W18O62)]·11H2O (H2biim = 2,2′-biimidazole) (1) was hydrothermally constructed by the reaction of Cu(II)-H2biim complexes and Dawson-type tungstophosphate, and characterized by single-crystal x-ray diffraction, IR spectroscopy (IR), X-ray powder diffraction (XRD), elemental anal. and electrochem. anal. Structural anal. showed that the polyanion [P2W18O62]6-, as a bidentate ligand, coordinates with two Cu2+ ions to form a bi-Cu(II)-supporting heteropolyanion [{Cu(H2biim)2}2(P2W18O62)]2-, which was surrounded by an isolated [Cu(H2biim)2(H2O)]2+ and eleven H2O mols. The presence of N-H···O/OW hydrogen bonds between H2biim mols. and polyoxoanion or water mols., in company with the synergistic effect of electrostatic interactions and π-π stack, gave a crystal material with 3-dimensional framework further. Compound 1 displayed good electrocatalytic activity toward the reduction of H2O2 and Na2NO2. Meanwhile it was also a good acid-catalyst for the synthesis of cyclohexanone ethylene ketal and could be recycled.

Yingyong Huaxue published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C17H14O5, COA of Formula: C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Wu, Haijun’s team published research in Renewable Energy in 192 | CAS: 1193-11-9

Renewable Energy published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C11H22N2O4, Safety of 2,2,4-Trimethyl-1,3-dioxolane.

Wu, Haijun published the artcilePromoting the conversion of poplar to bio-oil based on the synergistic effect of alkaline hydrogen peroxide, Safety of 2,2,4-Trimethyl-1,3-dioxolane, the publication is Renewable Energy (2022), 107-117, database is CAplus.

The synergistic catalysis effect of NaOH and H2O2 on the hydrothermal liquefaction (HTL) of poplar was investigated and compared to the NaOH or H2O2 catalyzed HTL at different temperatures and 30 min residence time. GC-MS, GPC, FT-IR, HPLC and TGA were used to comprehensively characterize the phys. and chem. properties of liquefied products (bio-oil, lignin and solid residue). The results showed that the highest total bio-oil yield (70.65%) was obtained at 280°C with NaOH (35 g/L)/H2O2 (30 g/L) as catalysts. The average mol. weight and polydispersity index (PDI) were found to be lower compared to that from other conditions. As the NaOH concentration was increased, the bio-oil yield was improved. The concentration of H2O2 for the optimal synergistic effect was observed to be 30 g/L. GC-MS anal. showed that the bio-oil obtained by NaOH (35 g/L)/H2O2 (30 g/L) was characterized with the lowest N content. The synergistic effect promoted the higher production selectivity of o-xylene and p-xylene in the bio-oil.

Renewable Energy published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C11H22N2O4, Safety of 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Tao, Duan-Jian’s team published research in Industrial & Engineering Chemistry Research in 51 | CAS: 177-10-6

Industrial & Engineering Chemistry Research published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H7NO4, Category: dioxole.

Tao, Duan-Jian published the artcileKinetics Study of the Ketalization Reaction of Cyclohexanone with Glycol Using Bronsted Acidic Ionic Liquids as Catalysts, Category: dioxole, the publication is Industrial & Engineering Chemistry Research (2012), 51(50), 16263-16269, database is CAplus.

It is remarkable that Bronsted acidic ionic liquids (BAILs) have several unique advantages in the acid-catalysis reaction, which avoids the tech. issues raised from mineral acids. The kinetics for the ketalization of cyclohexanone with glycol using BAILs as catalysts was therefore studied for the first time. The effects of various parameters such as kind of BAILs, temperature, catalyst loading, and molar ratio of the reactants on the conversion of cyclohexanone were examined in detail, and a pseudohomogeneous (PH) kinetic model was used successfully to correlate the exptl. data at from 313.15 to 343.15 K. The kinetic parameters such as reaction rate constant, activation energy, and chem. equilibrium constant then were proposed and utilized to interpret the catalytic activities of the BAILs catalysts. It was also validated from the comparison of catalytic performance among the BAILs, H2SO4, and solid resin that the BAILs were considered to be environmentally friendly and high efficient catalysts, and were suggested to replace mineral and solid acids in the synthesis of ketal.

Industrial & Engineering Chemistry Research published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H7NO4, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Chen, Wen-long’s team published research in Guangzhou Huagong in 44 | CAS: 177-10-6

Guangzhou Huagong published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Application of 1,4-Dioxaspiro[4.5]decane.

Chen, Wen-long published the artcilePreparation and catalytic application of SO42-/SnO2-WO3/KIT-6 complex solid acid, Application of 1,4-Dioxaspiro[4.5]decane, the publication is Guangzhou Huagong (2016), 44(7), 1-4, database is CAplus.

Complex solid acid of SO42-/SnO2-WO3/KIT-6 was prepared through impregnation method using KIT-6 as template. The solid acid was used as catalyst for the Baeyer-Villiger oxidation of cyclic ketones and the condensation reaction between ketones/aldehyde and diols. It was found that the synthesized solid acid exhibited promising catalytic activity in the two kinds of reactions. The introducing of the WO3 and KIT-6 increased not only the acidity but also the specific area of the solid acid, therefore, the catalytic activity of the solid acid was enhanced.

Guangzhou Huagong published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Application of 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Lu, Yueqing’s team published research in Bulletin of Materials Science in 35 | CAS: 177-10-6

Bulletin of Materials Science published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Related Products of dioxole.

Lu, Yueqing published the artcileSynthesis of novel carbon/silica composites based strong acid catalyst and its catalytic activities for acetalization, Related Products of dioxole, the publication is Bulletin of Materials Science (2012), 35(3), 419-424, database is CAplus.

Novel solid acid based on carbon/silica composites are synthesized through one-pot hydrothermal carbonization of hydroxyethylsulfonic acid, sucrose and tetra-Et orthosilicate (TEOS). The novel solid acid owned the acidity of 20 mmol/g, much higher than that of the traditional solid acids such as Nafion and Amberlyst-15 (08 mmol/g). The catalytic activities of the solid acid are investigated through acetalization. The results showed that the novel solid acid was very efficient for the reactions. The high acidity and catalytic activities made the novel carbon/silica composites based solid acid hold great potential for the green chem. processes.

Bulletin of Materials Science published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem