Category: Dioxole

Zhong, Feng published the artcileConstruction of Chiral 2,3-Allenols through a Copper(I)-Catalyzed Asymmetric Direct Alkynylogous Aldol Reaction, Computed Properties of 503538-69-0, the publication is Angewandte Chemie, International Edition (2020), 59(4), 1562-1566, database is CAplus and MEDLINE.

Chiral 2,3-allenols were constructed through copper(I)-catalyzed asym. direct alkynylogous aldol reaction. With aromatic and heteroaromatic aldehydes, the alkynylogous aldol reaction with (R)-DTBM-SEGPHOS as the ligand proceeded smoothly to furnish the products in excellent regioselectivity with good to high diastereoselectivity and excellent enantioselectivity. In the cases of aliphatic aldehydes, esters of but-2-yn-1-ol as the substrates and (R,R)-Ph-BPE as the ligand are crucial to get good to high regio- and diastereoselectivity. The produced chiral 2,3-allenols are easily transformed into synthetically useful 2-furanones through cyclization. Finally, the developed method was successfully applied in the rapid synthesis of two chiral intermediates toward the synthesis of two pharmaceutically active compounds that are proposed for the treatment of neurol. disorders.

Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C19H21N3O3S, Computed Properties of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Shuqing, Wang published the artcileSynthesis of the vanillin 1,2 – propylene glycol acetal catalyzed by strong acid cation exchange resin, Category: dioxole, the publication is Jingxi Shiyou Huagong Jinzhan (2008), 9(7), 17-19, database is CAplus.

Vanillin 1,2-propylene glycol acetal was synthesized using 1,2-propylene glycol and vanillin as starting materials and strongly acidic cation exchange resin as catalyst. The effect of reaction temperature, reaction time, materials ratio, and the amounts of catalyst on the synthesis was studied, and the proper technol. conditions were given as follows: vanillin was 0.1mol, n(1,2-propanediol):n(vanillin) was 2.2; reaction temperature was 90-95°C, reaction time was 3.5 h, the amount of strongly acidic cation exchange resin was 1 g; and the water-carrying agent (cyclohexane) was 30 mL. The yield of vanillin 1,2-propylene glycol acetal can reach 84.86%. Purity of the vanillin 1,2-propylene glycol acetal is 98.5% and the catalysts can be used repeatedly.

Jingxi Shiyou Huagong Jinzhan published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C9H21NO3, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Mykhailiuk, Pavel K. published the artcile1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery: design, synthesis and characterization, HPLC of Formula: 177-10-6, the publication is Tetrahedron (2013), 69(20), 4066-4075, database is CAplus.

1-Amino-4,4-difluorocyclohexanecarboxylic acid has been designed as a fluorinated analog of the pharmacol. relevant 1-aminocyclohexanecarboxylic acid. The synthesis has been performed in three steps from a com. available material in 22% overall yield. An impact of fluorine atoms on conformation, lipophilicity, acidity and fluorescent properties of the amino acid has been studied. Various practical applications of the obtained compound are suggested.

Tetrahedron published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, HPLC of Formula: 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Umeda, Rui published the artcileDesymmetrization of 1,4-Cyclohexadienyltriisopropoxysilane Using Copper Catalysis, Application In Synthesis of 503538-69-0, the publication is Organic Letters (2007), 9(11), 2175-2178, database is CAplus and MEDLINE.

The first catalytic desymmetrization in the field of allylsilane chem. is presented. Desymmetrization of cyclohexadienyltriisopropoxysilane is achieved using copper catalysis. High diastereo- and enantioselectivities are obtained, and the product dienes are highly valuable building blocks for natural product synthesis.

Organic Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C7H5Cl2NO, Application In Synthesis of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Mao, Deshou published the artcileAnalysis of volatile constituents from cocoa extract (Theobroma cacao. L) by using stir bar sorptive extraction-thermal desorption/gas chromatography-mass spectrometry, Product Details of C11H14O4, the publication is Xiangliao Xiangjing Huazhuangpin (2012), 5-9, 13, database is CAplus.

The volatile constituents of Cocoa extract were identified by using stir bar sorptive extraction-thermal desorption/gas chromatog.-mass spectrometry (SBSE-TDU/GC-MS). With the MS library search and retention index comparison, 73 compounds were confirmed with PDMS twister, and the main constituents included isovaleric acid (25.28%), isovaleraldehyde propylene glycol acetal (14.57%), benzyl acetate (10.60%), 1,2-propylene glycol (9.17%), phenethyl alc. (9.00%), dibenzyl ketone (5.00%), phenethyl phenylacetate (4.50%), isoamyl isovalerate (3.63%), 2,3,5-trimethylpyrazine (2.34%), 2-methoxy-3-Me pyrazine (2.29%), 2-isopropyl-5-methyl-2-hexenal (1.53%), Et linoleate (1.25%) and acetic acid (1.10%), while with EG-silicone twister, 59 chems. were determined, which included the following main compounds: 2,3,5-trimethylpyrazin (63.59%), acetic acid (12.06%), isovaleraldehyde propylene glycol acetal (4.96%), benzyl acetate (3.92%), palmitic acid (1.89%), guaiacol (1.41%), isovaleric acid (1.08%), dibenzyl ketone (1.08%) and glycerin (1.01%). The research provided technol. supports for exploitation and quality control of cocoa extract

Xiangliao Xiangjing Huazhuangpin published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Product Details of C11H14O4.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Meslard, J. C. published the artcileSynthesis of cyclic acetals under mild conditions. Applications to the acetalization of chloramphenicol, Quality Control of 1193-11-9, the publication is Bulletin de la Societe Chimique de France (1985), 84-9, database is CAplus.

Acetalization of 1-2 and 1-3 diols, even as sterically crowded as chloramphenicol, by carbonyl derivatives with substituents of various sizes has been performed at room temperature under mild conditions, by using heterogeneous catalysis (sulfonated polystyrene) in the presence of mol. sieves. Several new acetals of chloramphenicol e.g. I, have thus been obtained in good yields, isolated and characterized.

Bulletin de la Societe Chimique de France published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Quality Control of 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Aida, Yukimasa published the artcileRhodium-Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of α,ω-Diynes with Unsymmetrical 1,2-Disubstituted Alkenes, Category: dioxole, the publication is Organic Letters (2016), 18(11), 2672-2675, database is CAplus and MEDLINE.

It has been established that a cationic rhodium(I)/axially chiral biaryl bisphosphine complex catalyzes the asym. [2 + 2 + 2] cycloaddition of α,ω-diynes with electron-rich and unstrained unsym. 1,2-disubstituted alkenes to give chiral multicyclic compounds with good yields and ee values. Interestingly, enantioselectivity highly depends on the structures of α,ω-diynes used presumably due to the presence of two distinct reaction pathways.

Organic Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Maj, Anna M. published the artcileSynthesis of new chiral 2-functionalized-1,2,3,4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines, Related Products of dioxole, the publication is Tetrahedron (2013), 69(44), 9322-9328, database is CAplus.

The asym. hydrogenation of a series of quinolines substituted by a variety of functionalized groups linked to the C2 carbon atom is providing access to optically enriched 2-functionalized 1,2,3,4-tetrahydroquinolines in the presence of in situ generated catalysts from [Ir(cod)Cl]₂, a bisphosphine, and iodine. The enantioselectivity levels were as high as 96% ee.

Tetrahedron published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Maj, Anna M. published the artcileHighly enantioselective hydrogenation of new 2-functionalized quinoline derivatives, Category: dioxole, the publication is Tetrahedron Letters (2012), 53(35), 4747-4750, database is CAplus.

The asym. hydrogenation of a new series of 2-functionalized quinolines has been developed in the presence of in situ generated catalysts obtained from [Ir(cod)Cl]₂/(R)-bisphosphine/I₂ combinations. The enantioselectivity levels were as high as 84-94% ee for the synthesis of 1,2,3,4-tetrahydroquinolines.

Tetrahedron Letters published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Petrov, D. A. published the artcileCatalytic reaction between polysubstituted 1,3-dioxolanes and diazoacetic ester, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2003), 46(6), 40-42, database is CAplus.

Polysubstituted 1,3-dioxolanes reacted stereoselectively with Et diazoacetate in the presence of BF₃·OEt₂, cupric triflate, or Rh₂(OAc)₄ as catalyst to give Et 1,4-dioxane-2-acetates.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem