Category: Dioxole

Selective, Orally Active 5-HT_1D Receptor Agonists as Potential Antimigraine Agents was written by MacLeod, Angus M.;Street, Leslie J.;Reeve, Austin;Jelley, Richard A.;Sternfeld, Francine;Beer, Margaret S.;Stanton, Josephine A.;Watt, Alan P.;Rathbone, Denise;Matassa, Victor G.. And the article was included in Journal of Medicinal Chemistry in 1997.Category: dioxole This article mentions the following:

The clin. effective antimigraine drug, sumatriptan, is a serotonin receptor agonist with equal affinity for the 5-HT_1B and 5-HT_1D subtypes. To determine whether a compound selective for the 5-HT_1D subtype would have the same clin. efficacy, but with reduced side effects, a structural exploration of non-selective compounds was carried out to identify features that would provide differential binding affinity for the two receptors. Functionalized piperazinylpropylindoles were shown to have high affinity for 5-HT_1D with binding selectivities greater than 100-fold with respect to 5-HT_1B. The meta-fluorophenethylpiperazine L-775,606 was highlighted as the first orally bioavailable, selective 5-HT_1D agonist. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Category: dioxole).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Optimization of Grignard ring-opening of α-brominated dioxolanes for the preparation of β-hydroxy-protected vinyl ethers by a three-step one-pot procedure was written by Andre, Mathieu;Letribot, Boris;Bayle, Martine;Mounetou, Emmanuelle;Chezal, Jean-Michel. And the article was included in Tetrahedron Letters in 2012.Reference of 3418-21-1 This article mentions the following:

Aliphatic, cyclic, and aromatic benzoate-protected γ-hydroxy enol ethers were prepared from α-brominated dioxolanes by a three-step reaction procedure and a one-pot protocol involving Grignard reagent formation, ring-opening, and final benzoate protection. E.g., addition of Mg to the α-brominated dioxolane (I), followed by treatment with NEt₃, then with benzoyl chloride gave 61% benzoate-protected γ-hydroxy enol ether (II). Addnl., tert-butyldiphenylsilyl, acetate, and 4,4′-dimethoxytrityl were also successfully used as alternative protecting groups. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Reference of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

New masked δ-lithio carbonyl compounds: preparation and synthetic applications was written by Gil, Juan F.;Ramon, Diego J.;Yus, Miguel. And the article was included in Tetrahedron in 1993.Recommanded Product: 118336-86-0 This article mentions the following:

The reaction of 2-(4-chlorobutyl)-1,3-dioxolanes I (R = H, Et, Ph; R¹ = Cl) or 2-(4-chlorobutyl)-2-ethyl-1,3-dithiane with an excess of lithium powder and a catalytic amount of naphthalene (8 mol %) in THF at -78° leads to a solution of the corresponding masked lithium δ-enolates, which react with different electrophiles (water, deuterium oxide, carbonyl compounds, carboxylic acid derivatives, dibenzyl disulfide or benzylideneaniline) to yield the expected products, e.g., I [R = H, R¹ = H, D, PhCH(OH), PhCH₂S]. In the presence of a catalytic amount of CuBr.Me₂S, the intermediate I (R = H, R¹ = Li) reacts with cyclohex-2-enone giving the compound I (R = H, R¹ = 3-oxocyclohexyl) through a conjugate addition The deprotection of the dioxolane moiety with 2 N HCl gives the expected functionalized carbonyl compounds In situ generated hydroxy aldehydes react with triethylsilane, allyltrimethylsilane, and trimethylsilyl cyanide to give alcs. [e.g., Et₂CH(CH₂)₅OH], dienic alcs. [e.g., Me₂C:CH(CH₂)₃CH(OH)CH₂CH:CH₂], and cyanooxepanes II (R² = H, R³ = Ph; R² = R³ = Me, Et; R²R³ = (CH₂)₅]. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Recommanded Product: 118336-86-0).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 118336-86-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

An eco-friendly and efficient synthesis of benzoylformic acid and methyl benzoylformate from styrene was written by Dai, Zhihong;Peng, Xinhua;Dong, Xiongzi;Shi, Chunjie;Rong, Yuan. And the article was included in Asian Journal of Chemistry in 2012.Recommanded Product: 3418-21-1 This article mentions the following:

The HBr/H₂O₂ system was found to be a highly efficient and green catalytic system for the selective oxidation of styrene. The method was utilized for the synthesis of phenylglyoxalic acid in excellent yields using water as solvent. Subsequent esterification is simple, highly efficient, and inexpensive by using TiO₂/SO₄^2- as catalyst. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A mild and efficient method for one-step α-haloacetalization of acetophenones using 1,3-dihalo-5,5-dimehtylhydantoin in ethylene glycol was written by Zheng, Zu Biao;Li, Zhong Zhou;Han, Bing Bing;He, Zai Ming;Shi, Teng Fei;Cheng, Peng. And the article was included in Tetrahedron Letters in 2015.Recommanded Product: 3418-21-1 This article mentions the following:

A mild and efficient method that could directly prepare α-haloacetal acetophenones from various acetophenones with 1,3-dihalo-5,5-dimehtylhydantoin (DBDMH/DCDMH) and ethylene glycol in good yields without catalysts was reported. The effects of solvents, 1,3-dihalo-5,5-dimehtylhydantoin, and reaction temperature were investigated. Under the optimal condition, most of α-haloacetal acetophenones were obtained in 65-97% yields. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

One-step synthesis of substituted 2-aryl-2-(bromoalkyl)-1,3-dioxolanes was written by Svoboda, Jiri;Palecek, Jaroslav;Dedek, Vaclav;Mostecky, Jiri. And the article was included in Collection of Czechoslovak Chemical Communications in 1984.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

Bromoketalization of p-RC₆H₄COCHR¹R² (R = H, Me₂CHCH₂, Ph, Me, R¹ = R² = H; R = Me₂CHCH₂, R¹ = H, R² = Me; R = H, R¹ = R² = Me) with ethylene glycol and pyridinium perbromide, dioxane dibromide or PhN⁺Me₃ Br₃^– gave 35-84% I. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and some reactions of indolo[2,1-c]-1,4-oxazinium perchlorates was written by Kibalny, A. V.;Nikolyukin, Yu. A.;Dulenko, V. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1994.Application of 3418-21-1 This article mentions the following:

Title compounds I (R = Me, Et, Pr, CHMe₂, CMe₃, Ph) were prepared by reaction of 1-phenacylskatole with RCO⁺ClO₄^–. I were converted to pyrazine analogs (II; R = alkyl), dimeric compounds (III; R¹ = H, Me), and indolotriazepine IV. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Application of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Cationic Gold Catalyzes ω-Bromination of Terminal Alkynes and Subsequent Hydroaddition Reactions was written by Leyva-Perez, Antonio;Rubio-Marques, Paula;Al-Deyab, Salem S.;Al-Resayes, Saud I.;Corma, Avelino. And the article was included in ACS Catalysis in 2011.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

Orthogonal σ,π-bisfunctionalization of terminal alkynes can be achieved with a cationic gold complex in catalytic amounts First, the terminal C-H bond is transformed to the corresponding bromoalkyne which is then activated toward nucleophilic attack. This reactivity correlates with the structural nature of isolated gold-alkyne complexes. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis, characterization, and structures of α-substituted selenenyl-acetophenones was written by Hodage, Ananda S.;Phadnis, Prasad P.;Wadawale, Amey;Priyadarsini, K. I.;Jain, Vimal K.. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2014.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

A series of α-substituted selenenyl acetophenone derivatives of the types, [PhC(OCH₂CH₂O)CH₂Se]₂, [PhC(OCH₂CH₂O)CH₂SeR], (PhCOCH₂Se)₂, and [PhCOCH₂SeR] were prepared These compounds were characterized by elemental analyses, IR and NMR (¹H, ¹³C, ⁷⁷Se) spectroscopy. The structures were established on the basis of the spectroscopic data and confirmed by single crystal x-ray diffraction anal. of bis(1-phenyldioxolonylmethyl) diselenide [monoclinic, space group I2/a, a 11.934 (3), b 10.872 (2), c 15.133 (6) Å, α 90.00, β 95.00, γ 90.00°, V 1955.3 (10) ų, Z 4] and bis(phenacyl) diselenide [orthorhombic, space group Pbca, a 8.705 (3), b 17.760 (9), c 19.517 (7) Å, α 90.00, β 90.00, γ 90.00°, V 3017 (2) ų, Z 8]. The former shows intramol. Se- – -O interaction, while the latter exhibits inter-mol. nonbonding Se- – -O interaction. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation and reactions of N-phenacyl-N-tosylhydroxylamine and -hydrazines was written by Wessig, Pablo;Henning, Hans Georg. And the article was included in Liebigs Annalen der Chemie in 1991.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

O-Alkyl-N-phenacyl-N-tosylhydroxylamines PhCOCH₂NTsOCH₂R (I; Ts = tosyl; R = H, Ph, p-BrC₆H₄) were prepared in two steps from O-alkylhydroxylamines. In the presence of a base, I undergo rearrangement and cleavage to N-tosylphenacylamine and aldehydes RCHO. N-Alkyl-N‘-phenacyl-N,N‘-ditosylhydrazines TsNR¹NR²Ts (R¹ = R² = CH₂COPh or CH₂CO₂Et; R¹ = CH₂COPh, R² = CH₂Ph) were obtained by stepwise treatment of N,N‘-ditosylhydrazine with alkyl halides and phenacyl bromide/potassium tert-butoxide/DMF. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem