Category: Dioxole

Chemical Absorption of Carbon Dioxide into Glycidyl Methacrylate Solution with Tetrabutylammonium Bromide was written by Park, Sang-Wook;Choi, Byoung-Sik;Lee, Byung-Don;Park, Dae-Won;Kim, Seong-Soo. And the article was included in Separation Science and Technology in 2006.HPLC of Formula: 13818-44-5 This article mentions the following:

The reaction for fixation of carbon dioxide was carried out in a semi-batch stirred tank of glycidyl methacrylate solution with tetrabutylammonium bromide as catalyst at 101.3 kPa. The measured rate of uptake of carbon dioxide was used to obtain the kinetic parameters for the reaction steps to form five membered cyclic carbonates, i.e., reversible reaction of glycidyl methacrylate with tetrabutylammonium bromide to form an intermediate and an irreversible reaction between carbon dioxide and the intermediate to form the cyclic carbonate. An empirical correlation formula between the reaction rate constants and the solubility parameters of the solvents, such as toluene, N-methyl-2-pyrrolidinone, and DMSO, is presented. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5HPLC of Formula: 13818-44-5).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.HPLC of Formula: 13818-44-5

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation of an affinity chromatography matrix for the selective purification of the dopamine D2 receptor from bovine striatal membranes was written by Clagett-Dame, Margaret;Schoenleber, Robert;Chung, Christine;McKelvy, Jeffrey F.. And the article was included in Biochimica et Biophysica Acta, Biomembranes in 1989.Formula: C12H14ClFO2 This article mentions the following:

A ligand affinity matrix has been developed and utilized to purify the dopamine D2 receptor ∼2100-fold from bovine striatal membranes. 3-[2-Aminoethyl]-8-[3-(4-fluorobenzoyl)propyl]-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (AES) was synthesized and used to prepare the affinity matrix by coupling to epoxy-activated Sepharose 6B (AES-Sepharose). AES (K_i ≈ 1.7 nM) is similar in potency to the parent compound, spiperone (K_i ≈ 0.8 mM), in competing for [³H]spiperone-binding activity. AES has no significant potency in competing for the dopamine D1 receptor as assessed by competition for [³H]SCH23390 binding (K₂ > 1 μM)9. Covalent photoaffinity labeling of the dopamine D2 receptor in bovine striatal membranes with N-(p-azido-m-[¹²⁵I]iodophenethyl)spiperone ([¹²⁵I]N₃-NAPS) was prevented by AES at nanomolar concentrations The dopamine D2 receptor was solubilized from bovine striatal membranes using 0.25% cholate in the presence of high ionic strength, followed by precipitation and subsequent treatment with 0.5% digitonin. Nearly 100% of the [³H]spiperone-binding activity in the cholate-digitonin solubilized preparation was adsorbed at a receptor-to-resin ratio of 2:1 (volume/volume). Dopamine D2 receptor was eluted from the affinity resin using a competing dopaminergic antagonist mol., haloperidol. Recovery of dopamine D2 receptor activity from the affinity matrix was ∼9% of the activity adsorbed to the resin. The [³H]spiperone-binding activity in AES-Sepharose affinity purified preparations is saturable and of high affinity (0.2 nM). Affinity-purified preparations maintain the ligand-binding characteristics of a dopamine D2 receptor as assessed by agonist and antagonist competition for [³H]spiperone binding. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Formula: C12H14ClFO2).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Asymmetric Sulfinylations of N-Methylephedrine-Modified Tri- or Tetraalkyl Zincates by Symmetric Diaryl Sulfoxides was written by Ruppenthal, Simon;Brueckner, Reinhard. And the article was included in European Journal of Organic Chemistry in 2018.Product Details of 4360-63-8 This article mentions the following:

Diethylzinc was treated with 1 or 2 equivalent of AlkMgCl or PhMgBr (preferably) or with 1 equivalent of nBuLi (less efficiently) for forming species – plausibly zincates – which were sulfinylated by diaryl sulfoxides to give racemic alkyl aryl sulfoxides in yields reaching 100 %. Dialkylzinc reagents were also activated by treatments with 1 or 2 equivalent of an enantiomerically pure alkylmagnesium β-aminoalkoxide. This worked best when the alkoxide stemmed from a dialkylmagnesium reagent and an equimolar amount of N-methyl-(-)-ephedrine. This second activation mode allowed sulfinylations of what was originally the dialkylzinc reagent with diaryl sulfoxides. This generated alkyl aryl sulfoxides with enantiomeric ratios up to 93:7 in up to 100 % yield. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Product Details of 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Sedative effects of inhaled Perilla frutescens essential oils on mice was written by Ota, Yue;Ito, Michiho. And the article was included in Journal of Natural Medicines in 2021.SDS of cas: 607-91-0 This article mentions the following:

Perilla frutescens is an ingredient for cooking and for Japanese traditional medicine formulations. Essential oils extracted from P. frutescens are classified according to their composition, which are genetically regulated. Here, we extracted five types of essential oil from P. frutescens and studied their sedative activities. We grew P. frutescens strains that give oils of type PK, PA, PP, EK, and C, and extracted the essential oils by hydrodistillation We then measured the spontaneous locomotor activity of mice who had inhaled the oils in an open field test. All types of essential oil except the PK type decreased the spontaneous locomotor activity of mice. The EDs were 4.0 x 10-3 to 4.0 x 10-2 mg/cage (PA type), 4.0 x 10-4 mg/cage (PP type), 4.0 x 10-5 mg/cage (EK type), and 4.0 x 10-5 to 4.0 x 10-3 mg/cage (C type). Our results show that the essential oils of type PA, PP, EK, and C have a sedative effect. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0SDS of cas: 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Nickel-Catalyzed Asymmetric Reductive Arylalkylation of Unactivated Alkenes was written by Jin, Youxiang;Wang, Chuan. And the article was included in Angewandte Chemie, International Edition in 2019.Recommanded Product: 2-(3-Bromopropyl)-1,3-dioxolane This article mentions the following:

Reported is an asym. reductive dicarbofunctionalization of unactivated alkenes [e.g., 1-bromo-2-(3-methylbut-3-en-1-yl)benzene + 4-bromobutyl acetate → I (69%, 94% ee)]. Under the catalysis of a Ni/BOX system, various aryl bromides, incorporating a pendant olefinic unit, were successfully reacted with an array of primary alkyl bromides in the presence of Zn as a reductant, furnishing a series of benzene-fused cyclic compounds bearing a quaternary stereocenter in high enantioselectivities. Notably, this reaction avoids the use of pregenerated organometallics and demonstrates high tolerance of sensitive functionalities. The preliminary mechanistic investigations reveal that this Ni-catalyzed reaction proceeds as a cascade consisting of migratory insertion and cross-coupling with a nickel(I)-mediated intramol. 5-exo cyclization as the enantiodetermining step. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Recommanded Product: 2-(3-Bromopropyl)-1,3-dioxolane).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 2-(3-Bromopropyl)-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Participation of hippocampal ionotropic glutamate receptors in histamine H₁ antagonist-induced memory deficit in rats was written by Masuoka, Takayoshi;Saito, Shunsuke;Kamei, Chiaki. And the article was included in Psychopharmacology (Berlin, Germany) in 2008.Related Products of 34023-62-6 This article mentions the following:

Pyrilamine, a selective histamine H₁ antagonist, impaired spatial memory, and decreased hippocampal theta activity during a radial maze task. We investigated the ameliorative effects of glutamatergic drugs on pyrilamine-induced spatial memory deficit and the decrease in hippocampal theta activity in rats. Drug effects were measured using an eight-arm radial maze with four arms baited. Hippocampal theta rhythm during the radial maze task was also recorded with a polygraph system using a telemetric technique. I.p. injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and a decrease in the amplitude and power of hippocampal theta waves. The working memory deficit and the decrease in hippocampal theta power were antagonized by intrahippocampal injection of d-cycloserine (1 μg/side), spermidine (10 μg/side), spermine (10 μg/side), aniracetam (1 μg/side), and 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP) (1 μg/side), but not Con A. These results clearly indicate that H₁ antagonist-induced working memory deficit, and the decrease in hippocampal theta activity was closely associated with hippocampal glutamatergic neurotransmission mediated by N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-5-yl(piperidin-1-yl)methanone (cas: 34023-62-6Related Products of 34023-62-6).

Benzo[d][1,3]dioxol-5-yl(piperidin-1-yl)methanone (cas: 34023-62-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 34023-62-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Reactions relating to carbohydrates and polysaccharides. XLIV. Synthesis of isomeric bicyclic acetal ethers was written by Hallonquist, E. G.;Hibbert, H.. And the article was included in Canadian Journal of Research in 1933.Computed Properties of C4H7ClO2 This article mentions the following:

3,5,7-Trioxabicyclo[2.2.2]octane (I), m. 99° and of high vapor pressure, results in 95% yield by the action of aqueous KOH at 100° on 1,3-bromoethylideneglycerol 2-benzoate ( Acid hydrolysis of I gives HOCH₂CHO and glycerol, hydrolysis at the acetal ether linkages taking place simultaneously. Glycerol α-benzoate (II), prepared in 98% yield (Fischer, Bergmann and Barwind, C. A. 15, 684), treated with tribromoparaldehyde gives 1,2-bromoethylideneglycerol 3-benzoate (III). III with aqueous KOH gives 3,6,8-trioxabicyclo[3.2.1]octane (IV), m. 56-7° and of high vapor pressure. III in this reaction compared with its isomer is fairly inert. IV on hydrolysis gives HOCH₂CHO and glycerol. I and IV show no indication of interconvertibility on solution in solvents or under the influence of heat (Haskelberg, C. A. 26, 3777). Glycerol (30 g.) and ClCH₂CH(OEt)₂ (50 g.), heated with stirring at 115° for 15 min., gave on distilling chloroethylideneglycerol, b₁₃, 130-4°, in 80% yield. Similarly there was prepared chloroethylideneglycol, b₁₃ 57°, chloroethylidenetrimethylene glycol, b₁₁ 60-2°, β-chloropropylideneglycerol, b₁₅ 129-35°, and β-bromopropylideneglycerol, b₁₈ 136-40°, in yields of 40, 60, 56 and 65%, resp. The application of this method to the synthesis of cyclic acetals from open-chain acetals is being used in the determination of the structure of carbohydrates and polysaccharides. In the experiment, the researchers used many compounds, for example, 2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1Computed Properties of C4H7ClO2).

2-Chloromethyl-1,3-dioxolane (cas: 2568-30-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C4H7ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Organotransition metal modified sugars Part 21. Synthesis of organometallic disaccharides bearing two monosaccharide moieties linked by a chromium carbene spacer was written by Janes, E.;Dotz, K. H.. And the article was included in Journal of Organometallic Chemistry in 2001.Category: dioxole This article mentions the following:

Organometallic disaccharides containing a chromium carbene spacer have been synthesized from tetramethylammonium acetyl(pentacarbonyl)chromate(-I) (1) in a two-step protocol. An acylation/alcoholysis sequence applying di(isopropylidene)-protected glucose, mannose, galactose and fructose afforded O-glycoside methylcarbene complexes 6-9 in 29-84% yield. Upon reaction with 1,2:3,4-di-O-isopropylidene-α-D-galacto-hexodiald-1,5-ose, activated by TiCl₄, they undergo a trans-selective aldol condensation to give a 53-89% yield of chromium vinylcarbene O,C-disaccharides which are promising candidates for subsequent benzannulation, cyclopropanation, Diels-Alder- and Michael addition reactions. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Category: dioxole).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

MOR zeolite supported Bronsted acidic ionic liquid: an efficient and recyclable heterogeneous catalyst for ketalization was written by Li, Zhang-Min;Zhou, Yan;Tao, Duan-Jian;Huang, Wei;Chen, Xiang-Shu;Yang, Zhen. And the article was included in RSC Advances in 2014.Product Details of 177-10-6 This article mentions the following:

In order to widen the application of ionic liquids as efficient and renewable heterogeneous catalysts, supported ionic liquids (SILs) have received considerable attention. A novel heterogeneous catalyst MOR zeolite supported Bronsted acidic ionic liquid (BAIL@MOR) was therefore prepared, characterized and applied in the ketalization reaction. The influences of reaction temperature, time, and catalyst loading have also been investigated in detail. Combined characterization results of XRD, FT-IR, SEM, TG-DTG and N₂ adsorption-desorption suggested that the BAIL [CPES-BSIM][HSO₄] was successfully immobilized on the surface of MOR zeolite by covalent bonds. Moreover, the catalytic performance tests demonstrated that the catalyst BAIL@MOR exhibited excellent catalytic activities in the ketalization of cyclohexanone with glycol, 1,2-propylene glycol and 1,3-butylene glycol under mild reaction conditions, as comparable with the homogeneous catalysis of the precursors [BSmim][HSO₄] and H₂SO₄. In addition, the catalyst BAIL@MOR was also found to be reusable five times without a significant loss of its catalytic activity. Thus, the heterogeneous catalyst BAIL@MOR can act as a promising candidate for the ketalization reaction. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Product Details of 177-10-6).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 177-10-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Novel sugar based acrylate: synthesis, characterization and polymerization was written by Koruyucu, Meryem;Saltan, Fehmi;Kok, Gokhan;Akat, Hakan;Salman, Yesim. And the article was included in Journal of Polymer Materials in 2019.Safety of (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol This article mentions the following:

The present study has demonstrated that novel acrylic glycopolymers are successfully prepared by using monosaccharides containing an acrylate group (9-12). For this purpose, sugar based acrylate monomers were synthesized via ring opening method (Method B) and homopolymerization of this sugar oxypropylacrylates was performed using free radical polymerization The characterization of all the monomers and polymers were verified by 1HNMR, 13CNMR, FTIR and GPC techniques. The Glass transition temperatures and thermal characteristics of the polymers were also analyzed by using DSC and TG techniques. The thermal stability of prepared polymers have changed with the stereochem. of the carbohydrate moiety. Also, the mol. weight of the polymers has affected the thermal stability. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Safety of (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem