Category: Dioxole

Catalytic synthesis of butanone glycol ketal with H₃PW₁₂O₄₀/TiO₂ was written by Yang, Shuijin;Li, Zhen;Lu, Baolan. And the article was included in Huaxue Gongye Yu Gongcheng Jishu in 2007.Recommanded Product: 126-39-6 This article mentions the following:

The butanone glycol ketal is synthesized from butanone and ethylene glycol in the presence of H₃PW₁₂O₄₀/TiO₂. The factors influencing the synthesis such as the molar ratio of butanone to ethylene glycol, the mass fraction of catalyst, the reaction temperature and the reaction time are discussed. The experiment shows that H₃PW₁₂O₄₀/TiO₂ is an excellent catalyst for synthesis of butanone glycol ketal. The optimum conditions are as follows: the molar ratio of butanone to ethylene glycol is 1:1.5, the mass fraction of catalyst is 1.6%, the reaction temperature is 76-99°C, the reaction time is 1.0h, and the water is removed with cyclohexane. The yield of butanone glycol ketal can reach over 60.3% at the optimum conditions. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Recommanded Product: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of vanillin 1,2-propylene glycol acetal catalyzed by silica supported ferric sulfate was written by Tu, Yuan-hong;Xiong, Bin;Liao, Wei-lin;Xu, Zhao-hui. And the article was included in Riyong Huaxue Gongye in 2008.Recommanded Product: 68527-74-2 This article mentions the following:

Vanillin 1,2-propylene glycol acetal was synthesized using 1,2 -propylene glycol and vanillin as starting materials and silica supported ferric sulfate as catalyst. Effects of factors on yield of product, such as molar ratio of the reactants, reaction time, catalyst dosage and its stability, were investigated. Exptl. results showed that the preferential conditions were as follows: based on 0.1 mol of vanillin, the molar ratio of vanillin to 1,2 -propylene glycol was 1.0: 1.4; the dosage of catalyst was 2.5% of the total weight of the reactants; the amount of cyclohexane as water stripping agent was 12 mL; the reaction time was 3.0 h; under these conditions, the yield could achieve 86.0%. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Recommanded Product: 68527-74-2).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 68527-74-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Triazoloamides as potent γ-secretase modulators with reduced hERG liability was written by Fischer, Christian;Zultanski, Susan L.;Zhou, Hua;Methot, Joey L.;Shah, Sanjiv;Nuthall, Hugh;Hughes, Bethany L.;Smotrov, Nadja;Hill, Armetta;Szewczak, Alexander A.;Moxham, Christopher M.;Bays, Nathan;Middleton, Richard E.;Munoz, Benito;Shearman, Mark S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Electric Literature of C7H5F2NO2 This article mentions the following:

Synthesis and SAR studies of novel aryl triazoles as gamma secretase modulators (GSMs) are presented in this communication. Starting from aryl triazole leads, optimization studies were continued and the series progressed towards novel amides and lactams. Triazole I was identified as the most potent analog in this series, displaying single-digit nanomolar Aβ42 IC₅₀ in cell-based assays and reduced affinity for the hERG channel. In the experiment, the researchers used many compounds, for example, 2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0Electric Literature of C7H5F2NO2).

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C7H5F2NO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of 1,3-dioxolanes from natural carbonyl compounds was written by Beresnevich, L. B.;Moiseichuk, K. L.. And the article was included in Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk in 2009.Product Details of 68527-74-2 This article mentions the following:

Condensation of various naturally occurring aldehydes and ketones R¹R²CO [R¹ = H, R² = n-Pr, i-Bu, 4-MeC₆H₄CH₂CHMe, 4-HO-3-MeOC₆H₃, etc.; R¹R² = (CH₂)₄, (CH₂)₅, etc.; R¹ = R² = n-Pr; R¹ = Me, R² = Et, t-Bu, n-hexyl] with 1,2-propanediol in the presence of sulfonated cationite FIBAN K-1 neat or in benzene gave the corresponding 1,3-dioxolanes in 50-98% yields. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Product Details of 68527-74-2).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Product Details of 68527-74-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of substituted 2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b]diazepine-7-sulfamides was written by Filimonov, S. I.;Kravchenko, D. V.;Khakhina, M. Yu.;Dorogov, M. V.;Tkachenko, S. E.;Ivashchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2005.Category: dioxole This article mentions the following:

Liquid-phase parallel synthesis of a combinatorial library of 320 2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-sulfonamides I (R¹, R² = H, Me; R³R⁴N = primary or secondary aliphatic, cycloaliphatic, aromatic or heterocyclic amine) was carried out by chlorosulfonylation of the corresponding benzodiazepines followed by reaction with primary and secondary amines. The pharmacol. important parameters of some of these compounds (mol. weight, lipophilicity and number of hydrogen bond donor and acceptors) have been calculated In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Category: dioxole).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of cyclohexanone ethylene ketal catalyzed by Keggin-type Ni/Cu/2,2′-H₂ biim-tungstosilicates was written by Zhu, Zai-ming;Wang, Yu;Yu, Zhan-jun;Wang, Qiu-xue;Du, Jing;Su, Fang. And the article was included in Yingyong Huagong in 2015.Name: 1,4-Dioxaspiro[4.5]decane This article mentions the following:

A series of Keggin-type Ni/Cu/H₂biim-tungstosilicates (H₂ biim = 2,2′-biimidazole) were synthesized with the parent tungstosilicic acid as a reactant and H₂ biim, Ni²⁺/Cu²⁺ and their complexes as raw materials by a direct precipitation method. They were characterized by single crystal XRD, IR and elemental anal. The acid-catalyzed synthesis of cyclohexanone ethylene ketal by the reaction of cyclohexanone with ethylene glycol was selected as a model reaction. The catalytic activities of these tungstosilicates were investigated. The results show that the introduction of large cation reduced the POM’s solubility, and the catalysts can be recycled and reused, so that their utilization can be improved. Moreover, the catalytic activities of these heterogeneous catalysts were almost unchanged after three cycles. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Name: 1,4-Dioxaspiro[4.5]decane).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Name: 1,4-Dioxaspiro[4.5]decane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Methyl iodide mediated cleavage of the nitrogen-oxygen bond of isoxazolidines was written by Van Boggelen, Michel P.;Van Dommelen, Bart F. G. A.;Jiang, Shende;Singh, Gurdial. And the article was included in Tetrahedron in 1997.Name: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol This article mentions the following:

A novel method of N-O bond cleavage in isoxazolidines is described. Treatment of isoxazolidine with excess of Me iodide in THF under reflux gave the quaternary ammonium iodide alc. and the α,β-unsaturated aldehyde. The former can be converted to the latter via the Swern oxidation In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Name: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Name: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

An ensuing repercussion of solvent alteration on biological and photocatalytic efficacy of Emilia sonchifolia (L.) phytochemicals capped zinc oxide nanoparticles was written by D’Souza, Josline Neetha;Nagaraja, G. K.;Meghana Navada, K.;Kouser, Sabia;Nityasree, B. R.;Manasa, D. J.. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2021.Computed Properties of C6H12O3 This article mentions the following:

In the framework of the present study, a triumphant attempt was made to obtain biocompatible ZnOES NPs using E. sonchifolia (L.) plant extracts A repercussion of solvent alteration on the biol. and photocatalytic properties of ZnOES NPs has also been delineated employing two solvents viz. water and ethanol during the extraction of plant material. The formation of ZnOES NPs was confirmed through FTIR, PXRD, and UV-visible spectroscopy, which was further upheld by the elemental mapping study. Addnl., the NPs were examined through Rietveld refinement of P-XRD data obtained, FE-SEM, and BET analyses. The results of these analyses have substantiated the formation of mesoporous ZnOES NPs with divergent shapes and sizes ranging between 18.12 and 25.70 nm. The in-vitro antidiabetic activity of ZnOES NPs carried out revealed their excellent α-amylase inhibition activity (85.53 ± 0.002%). Furthermore, the in-vitro anti-inflammatory activity unfolded their biocompatibility by exhibiting a % HRBCMS up to 89.31 ± 0.002%. The NPs also displayed anti-microbial activities against Staphylococcus aureus, Bacillus subtulis, Pseudomonas aeroginosa, Pseudomonas syringae, and Escherichia coli. Therewithal the photo-degradation experiments of ZnOES nanocatalysts manifested superlative dye degradation efficacies exhibiting a % degradation of 92.01 and 79.36 for Methylene Blue and Methyl orange dyes resp. Thus the studies have evinced the antidiabetic, antimicrobial, and dye degradation potentialities of biocompatible ZnOES NPs with excellent stability and reusability. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8Computed Properties of C6H12O3).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C6H12O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Total Synthesis of (-)-Anominine was written by Bradshaw, Ben;Etxebarria-Jardi, Gorka;Bonjoch, Josep. And the article was included in Journal of the American Chemical Society in 2010.Name: 2-Ethyl-2-methyl-1,3-dioxolane This article mentions the following:

The first total synthesis of anominine [(-)-I] has been achieved, and the absolute configuration of the product has been determined The key features include the development of a new, highly efficient organocatalyzed method for the asym. synthesis of Wieland-Miescher ketone building blocks, an unusual selenoxide [2,3]-sigmatropic rearrangement, and a ZrCl₄-catalyzed indole coupling as well as several chemoselective transformations controlled by the structurally congested nature of the bicyclic core. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Name: 2-Ethyl-2-methyl-1,3-dioxolane).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Name: 2-Ethyl-2-methyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Total synthesis of (-)-isoaltholactone was written by Liu, Jun;Zhang, Xing;Liu, Yi;Bi, JingJing;Du, YuGuo. And the article was included in Science China: Chemistry in 2013.Name: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol This article mentions the following:

A short and efficient stereoselective synthesis of a styryllactone (-)-isoaltholactone, I, has been achieved in seven steps and 33% overall yield, starting from the readily available carbohydrate D-mannose. The key steps of our synthesis involve intramol. THF cyclization and one-pot acetonide deprotection-lactonization. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Name: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Name: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem