Category: Dioxole

Copper complexes bearing an NHC-calixarene unit: synthesis and application in click chemistry was written by Ourri, Benjamin;Tillement, Olivier;Tu, Tao;Jeanneau, Erwann;Darbost, Ulrich;Bonnamour, Isabelle. And the article was included in New Journal of Chemistry in 2016.Formula: C4H7BrO2 This article mentions the following:

The synthesis of N-heterocyclic carbene (NHC) copper complexes supported by calix[4]arene is reported. Mono-substituted calix[4]arene was prepared through conventional procedures, followed by the attachment of an imidazolyl group to create the precursor of NHC ligands. Alkylation with two alkyl bromides followed by metalation resulted in fully characterized original complexes. The x-ray structure showed an “out” conformation for copper. The catalytic activity of the complexes was studied in click chem., and revealed good performances. In particular, three new triazoles were synthesized in high yields, under solvent-free conditions and a fast reaction time. The newly synthesized chiral complex was tested in the kinetic resolution of racemic azide. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Formula: C4H7BrO2).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C4H7BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

4-Aminoquinolines Bearing a 1,3-Benzodioxole Moiety: Synthesis and Biological Evaluation as Potential Antifungal Agents was written by Yang, Rui;Li, Zhuolin;Xie, Jialing;Liu, Jianchuan;Qin, Tianhong;Liu, Junda;Du, Haiying;Ye, Haoyun. And the article was included in Chemistry & Biodiversity in 2021.Electric Literature of C9H9NO3 This article mentions the following:

In search of new environmentally friendly and effective antifungal agents, a series of 4-aminoquinolines bearing a 1,3-benzodioxole moiety were prepared and their structures were fully elucidated by spectroscopic analyses. The antifungal activities of all the target compounds against five phytopathogenic fungi were evaluated in vitro. The results revealed that most of the newly synthesized compounds exhibited obvious inhibitory activities at the concentration of 50μg/mL. Among them, compound I displayed more promising antifungal potency with EC₅₀ values of 10.3 and 14.0μg/mL against C. lunata and A. alternate, resp. Particularly, the EC₅₀ value of I against C. lunata was 7.3-fold as potent as the standard azoxystrobin. There were some significant morphol. alterations in the mycelia of C. lunata when treated with I at 50μg/mL. Addnl., the preliminary structure-activity relationships (SARs) were also discussed. Thus, this study suggests that 4-aminoquinolines bearing a 1,3-benzodioxole moiety are interesting scaffolds for the development of novel antifungal agents. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Electric Literature of C9H9NO3).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C9H9NO3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Organocatalytic enantioselective conjugate addition of 2-nitrocyclohexanone to acrylaldehyde: a concise two-step synthesis of chiral building block 1-azaspiro[4.5]decan-6-one was written by Ding, Xiao-Hua;Cui, Wei-Chen;Li, Xiang;Ju, Xuan;Liu, Dan;Wang, Shaozhong;Yao, Zhu-Jun. And the article was included in Tetrahedron Letters in 2013.Recommanded Product: 126-39-6 This article mentions the following:

A gram-scale organocatalytic enantioselective Michael addition of α-nitrocyclohexanone to acrolein has been developed, and it was successfully applied to a concise two-step synthesis of (1S)-azaspiro[4.5]decan-6-one I, a useful chiral building block for the synthesis of a variety of natural alkaloids. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Recommanded Product: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Integrative omic analysis reveals the improvement of alkaloid accumulation by ultraviolet-B radiation and its upstream regulation in Catharanthus roseus was written by Zhong, Zhuoheng;Liu, Shengzhi;Han, Songling;Li, Yaohan;Tao, Minglei;Liu, Amin;He, Qiang;Chen, Sixue;Dufresne, Criag;Zhu, Wei;Tian, Jingkui. And the article was included in Industrial Crops and Products in 2021.HPLC of Formula: 607-91-0 This article mentions the following:

Indole alkaloids from Catharanthus roseus (L.) G. Don were valued for their wide spectrum of pharmaceutical effects. Their biosynthesis is modulated by various abiotic factors including UV B radiation which induced ATP production and led to accumulation of indole alkaloids. To investigate the regulatory mechanism of secondary metabolism in the leaf mitochondria of C. roseus under UV B radiation, combinatory study of proteomic and metabolomic analyses of C. roseus was performed. ATP export in the leaves of C. roseus increased under UVB radiation, which required mitochondrial ATP synthase. Proteins related to mitochondrial complexes II/IV and their gene expression levels increased, and those related to mitochondrial complex I decreased. Proteins related to the methylerythritol phosphate pathway, especially geranylgeranyl pyrophosphate synthase, increased under UV B radiation. Metabolites whose levels changed were mainly alkaloids, organic acids, carbohydrates, phenylpropanoids, and fatty acids, while eight indole alkaloids increased. Integrative anal. of omics data indicated that the metabolism of glutamate and tyrosine was downregulated. These results suggest that UV B radiation induces dynamic changes in mitochondria in C. roseus, which guarantees ATP production, regulates the flux of the methylerythritol phosphate pathway to the biosynthesis of monoterpene moieties, and leads to accumulation of various indole alkaloids. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0HPLC of Formula: 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.HPLC of Formula: 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation and catalytic activity of SO₄^2-/TiO₂-WO₃ was written by Yang, Shui-Jin;Bai, Ai-Min;Yu, Xie-Qing;Sun, Ju-Tang. And the article was included in Youji Huaxue in 2004.Formula: C6H12O2 This article mentions the following:

A novel solid superacid catalyst, SO₄^2-/TiO₂-WO₃, was prepared Its catalytic activity for twelve important ketals and acetals was measured with esterification of butyric acid with Bu alc. as probing reaction. The preparation conditions of SO₄^2-/TiO₂-WO₃ have also been investigated, i.e., the mass ratio of the H₂WO₄ used in the compound is 12.5%, the calcining temperature is 580°, the calcining time is 3 h, and the soaked consistency of H₂SO₄ is 1.0 mol/L^-1. Exptl. results showed that S0₄^2-/TiO₂-WO₃ is an excellent catalyst for the synthesis of twelve important ketals and acetals. The optimum reaction conditions are that the molar ratio of aldehyde/ketone to glycol is 1:1.5, the mass ratio of the catalyst used in the reactants is 0.5%, and the reaction time is 1.0 h. Under these conditions, the yield of 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane is 78.7%, 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane 83.0%, cyclohexanone ethylene ketal 85.9%, cyclohexanone 1,2-propanediol ketal 84.6%, butanone ethylene ketal 70.7%, butanone 1,2-propanediol ketal 88.3%, 2-propyl-1,3-dioxolane 80.6%, 4-methyl-2-propyl-1,3-dioxolane 79.6%, 2-isopropyl-1,3-dioxolane 64.2%, 4-methyl-2-isopropyl-1,3-dioxolane 83.3%, 2-phenyl-1,3-dioxolane 75.3%, 4-methyl-2-phenyl-1,3-dioxolane 95.1%, resp. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Formula: C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228 was written by Reck, Folkert;Bermingham, Alun;Blais, Johanne;Capka, Vladimir;Cariaga, Taryn;Casarez, Anthony;Colvin, Richard;Dean, Charles R.;Fekete, Alex;Gong, Wanben;Growcott, Ellie;Guo, Hongqiu;Jones, Adriana K.;Li, Cindy;Li, Fengxia;Lin, Xiaodong;Lindvall, Mika;Lopez, Sara;McKenney, David;Metzger, Louis;Moser, Heinz E.;Prathapam, Ramadevi;Rasper, Dita;Rudewicz, Patrick;Sethuraman, Vijay;Shen, Xiaoyu;Shaul, Jacob;Simmons, Robert L.;Tashiro, Kyuto;Tang, Dazhi;Tjandra, Meiliana;Turner, Nancy;Uehara, Tsuyoshi;Vitt, Charles;Whitebread, Steven;Yifru, Aregahegn;Zang, Xu;Zhu, Qingming. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.SDS of cas: 15186-48-8 This article mentions the following:

Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-neg. bacteria to all classes of β-lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clin. utility against MBL-expressing strains because they are impacted by serine β-lactamases (SBLs), which are often co-expressed in clin. isolates. Here, we optimized novel monobactams for stability against SBLs, which led to the identification of LYS228 (compound 31). LYS228 is potent in the presence of all classes of β-lactamases and shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae (CRE). In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8SDS of cas: 15186-48-8).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 15186-48-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Asymmetric synthesis of (2’R,4’R) and (2’S,4’S)-1,3-dioxolanyl triazole C-nucleosides was written by Qu, Fucheng;Hong, Joon H.;Du, Jinfa;Newton, M. Gary;Chu, Chung K.. And the article was included in Tetrahedron in 1999.HPLC of Formula: 114746-70-2 This article mentions the following:

In view of biol. activities of both 1,3-dioxolanyl nucleosides and C-nucleosides, D- and L-1,3-dioxolanyl C-nucleosides have been synthesized as potential antiviral and/or anticancer agents. Asym. synthesis of four new optically pure D- and L-1,3-dioxolanyl triazole C-nucleosides has been accomplished via key intermediates 5-[(1R/S)-glycol-1-yl]-3-ethoxycarbonyl-1-benzyl-1H-1,2,4-triazole starting from D- and L-2,3-O-isopropylidene glyceraldehyde. The stereochem. assignments of synthesized compounds were unambiguously made based on NMR studies as well as X-ray crystallog. studies. The synthesized nucleosides have been evaluated against HIV and hepatitis B virus, however, no significant antiviral activity was observed In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid (cas: 114746-70-2HPLC of Formula: 114746-70-2).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid (cas: 114746-70-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.HPLC of Formula: 114746-70-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Chemical composition and biological activity of the volatile oils of Hyptis spicigera against Trypanosoma brucei brucei, (Tbb) found in Northern Nigeria was written by Ladan, Z.;Amupitan, J. O.;Oyewale, O. A.;Okonkwo, E. M.;Ladan, E. O.;Odjobo, B.;Habila, N.. And the article was included in African Journal of Pure and Applied Chemistry in 2011.COA of Formula: C8H14O2 This article mentions the following:

The hydrodistillation of the fresh leaves of Hyptis spicigera gave a colorless volatile oil with yield of 0.65%. The volatile oil gave forty compounds on the basis of gas chromatog.-mass spectroscopy (GC-MS) with low composition of cineole (4.11%) and caryophyllene (2.61%) while α-pinene (12.16%) β-pinene (9.47%) and α-phellandrene (10.19%) were predominant compounds The biol. activity of the volatile oils was evaluated in vitro for activity against Trypanosoma brucei brucei (Tbb) and was found to possess anti-trypanosoma activity in vitro in a dose dependent pattern at 0.5 μg/mL in 6 min. This activity showed the volatile oils from H. spicigera leaves to be a potential trypanocide. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6COA of Formula: C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.COA of Formula: C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of acetals or ketals via acetalization or ketalization of aldehydes or ketones with glycols using titania-supported molybdotungstophosphoric acid (H₃Mo₆PW₆O₄₀) as catalyst was written by Yang, Shuijin;Tong, Wenlong. And the article was included in Xiyou Jinshu Cailiao Yu Gongcheng in 2007.Category: dioxole This article mentions the following:

A new environmentally friendly catalyst, H₃PW₆Mo₆O₄₀/TiO₂ is reported here. Optimized reaction conditions involved: mass ratio of m(TiO₂):m(H₃PW₆Mo₆O₄₀) 1/2.0, volume of water 30 mL, the reflux reaction time 2 h, activated temperature 150°. H₃PW₆Mo₆O₄₀/TiO₂ was used as catalyst in the synthesis of acetals and ketals, namely cyclohexanone ethylene ketal (i.e., 1,4-dioxaspiro[4.5]decane), cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane, 4-methyl-2-propyl-1,3-dioxolane. Effects of n(aldehyde/ketone):n(glycol), catalyst dosage and reaction time on yield were investigated. Optimized reaction conditions were: n(aldehyde/ketone):n(glycol) = 1.0:1.4; mass fraction of catalyst to reactants, 0.8%; reaction time, 1.0 h and cyclohexane as water-stripping reagent, 10 mL. Under these conditions, yield of cyclohexanone ethylene ketal, cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane and 4-methyl-2-propyl-1,3-dioxolane were 81.3%, 86.9%, 53.0%, 66.9%, 72.3%, 79.0%, 66.8%, 76.9% resp. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Category: dioxole).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In-chain functionalized poly(ε-caprolactone): A valuable precursor towards the synthesis of 3-miktoarm star containing hyperbranched polyethylene was written by Al-Sulami, Ahlam;Ladelta, Viko;Hadjichristidis, Nikos. And the article was included in Journal of Polymer Science (Hoboken, NJ, United States) in 2020.Quality Control of (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol This article mentions the following:

Well-defined 3-miktoarm star copolymer 3μ-HBPE(PCL)₂ (HBPE: hyperbranched polyethylene, PCL: poly[ε-caprolactone]) was synthesized by combining chain walking polymerization (CWP), ring-opening polymerization (ROP), and “click” chem. The synthetic methodol. includes the following steps: (a) synthesis of in-chain ethynyl-functionalized PCL, (PCL)₂-C CH by ROP of ε-caprolactone (CL) with ethylene-functionalized solketal (3-[prop-2-yn-1-yloxy] propane-1,2-diol) as difunctional initiator and phosphazene superbase t-BuP₂ as catalyst; (b) synthesis of azido-functionalized hyperbranched PE (HBPE-N₃) by CWP of ethylene with α-diimine-Pd(II) catalyst, followed by quenching with excess 4-vinylbenzyl chloride and transformation of chloro to azide group with sodium azide; and (c) “clicking” HBPE-N₃ and (PCL)₂-C CH using copper(I)-catalyzed azide-alkyne cycloaddition ¹H NMR spectroscopy, gel permeation chromatog., Fourier-transform IR spectroscopy, and differential scanning calorimetry were used to determine the mol. characteristics and thermal properties of the polymers. Self-assembly behavior of 3μ-HBPE (PCL)₂ in petroleum ether, a selective solvent for HBPE, was investigated by dynamic light scattering, at. force microscopy, and transmission electron microscopy. The in-chain alkyne-functionalized poly(ε-caprolactone) is a valuable precursor for PCL-based complex macromol. architectures. In the experiment, the researchers used many compounds, for example, (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8Quality Control of (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol).

(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (cas: 100-79-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Quality Control of (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem