Category: 7524-52-9

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7524-52-9, is researched, SMILESS is N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl, Molecular C12H15ClN2O2Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry Letters called Design, synthesis and bio-evaluation of C-1 alkylated tetrahydro-β-carboline derivatives as novel antifungal lead compounds, Author is Singh, Rahul; Jaisingh, Aanchal; Maurya, Indresh K.; Salunke, Deepak B., the main research direction is alkylated tetrahydrocarboline design synthesis Candida antifungal; Antifungals; Apoptosis; Candida glabrata; Pictet-Spengler; SAR; Synergistic effect; β-Carboline.Category: dioxole.

The field of antifungal agent has become static and development of resistance by the pathogen as well as limited clin. efficacy of marketed drugs demand the constant development of new antifungals. The presence of hydrocarbon chain of specific length linked with various different heterocycles was found to be an important structural feature in various antifungal lead compounds Based on the prominent antimicrobial activity of β-carboline derivatives, a set of C1 alkylated tetrahydro-β-carboline derivatives were proposed to be active against fungi. To validate and confirm the role of suitable alkyl chains linked to a β-carboline scaffold, few related analogs having C1 aryl substituents were also synthesized in one step via classic Pictet-Spengler reaction. The synthesized library was evaluated for its antifungal activity against C. albicans, C. krusei, C. parapsilosis, C. kefyr, C. glabrata, C. tropicalis and C. neoformans. One of the library members I, with n-alkyl chain of eight carbons exhibited potent antifungal activity against C. glabrata and C. kefyr. The lead compound, being selectively toxic also demonstrated prominent synergy enhancing the potency of antifungal drugs up to 10-fold. The time kill kinetic studies confirmed the efficacy of compound I, where the results obtained were comparable to that of Amp B. FE-SEM anal. revealed the increased asymmetry, disintegration and roughness of cell surface which could be because of the possible interaction of compound I at membrane level or interference in cell wall structure. Apoptosis/necrosis detection assay confirmed the significant apoptotic activity in C. glabrata cells after I treatment which was responsible for the rapid killing of C. glabrata cells.

In some applications, this compound(7524-52-9)Category: dioxole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Saito, Masato; Murakami, Sho; Nanjo, Takeshi; Kobayashi, Yusuke; Takemoto, Yoshiji published an article about the compound: H-Trp-OMe.HCl( cas:7524-52-9,SMILESS:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl ).HPLC of Formula: 7524-52-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:7524-52-9) through the article.

A mild and chemoselective method for the thioacylation of amines using α-keto acids and elemental sulfur has been developed. The key to the success of this transformation is the nucleophilic activation of elemental sulfur by thiols such as 1-dodecanethiol. A variety of functional groups, including unprotected hydroxyl, carboxyl, amide, sulfide, and tertiary amine moieties, are tolerated under the applied reaction conditions. To demonstrate the advantages of this method compared with conventional O-S exchange reactions using Lawesson’s reagent or P2S5, thioamide moieties were introduced site-specifically into biol. active compounds

In some applications, this compound(7524-52-9)HPLC of Formula: 7524-52-9 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Construction of thioamide peptide via sulfur-involved amino acids/amino aldehydes coupling, published in 2021-11-19, which mentions a compound: 7524-52-9, Name is H-Trp-OMe.HCl, Molecular C12H15ClN2O2, Application In Synthesis of H-Trp-OMe.HCl.

A sulfur-involved ligation for thioamide quasi-peptides was developed via amino acids and amino aldehydes coupling. The key to the transformation was the chelation of copper with imines for chiral activation and fixation. In this environment, linear polysulfur decreased the alkalinity of single sulfur anions to prevent racemization caused by the interaction between sulfur and sodium sulfide. Dipeptides, tripeptides, tetrapeptides, and the linkage between the drug and amino acids were successfully obtained.

In some applications, this compound(7524-52-9)Application In Synthesis of H-Trp-OMe.HCl is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Quality Control of H-Trp-OMe.HCl. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Synthesis, characterization and antioxidant activity of chitosan Schiff base derivatives bearing (-)-gossypol. Author is Beyazit, Neslihan; Cakran, Halide Sinem; Cabir, Ali; Akiscan, Yasar; Demetgul, Cahit.

In this work, two new chitosan-Schiff base derivatives (HCS-GSP and LCS-GSP) were synthesized by the condensation reaction of high mol. weight chitosan (HCS) and low mol. weight chitosan (LCS) with (-)-gossypol (GSP), resp. For this purpose, racemic gossypol was isolated from cotton seeds and it was further enantiomerically purified by diastereomeric resolution technique using L-tryptophan Me ester hydrochloride. Then, chitosan polymers were derivatized with (-)-gossypol by the condensation reaction. The isolated and synthesized compounds were characterized by phys. measurements and spectroscopic methods (elemental anal. C,H,N, Uv-vis, FT-IR, 1H&13C NMR and TG/DTG/DTA). The antioxidant activity of high mol. weight chitosan (HCS), low mol. weight chitosan (LCS) and their gossypol derivatives was evaluated as radical scavengers against 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH). The results showed that both of the chitosan-gossypol derivatives (HCS-GSP and LCS-GSP) had a better ability to scavenging DPPH radical (IC50, 12 μg/mL and 16 μg/mL, resp.) than its unmodified chitosan.

In some applications, this compound(7524-52-9)Quality Control of H-Trp-OMe.HCl is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The first tryptophan based turn-off chemosensor for Fe2+ ion detection》. Authors are Nagarajan, Rajendran; Vanjare, Balasaheb D.; Hwan Lee, Ki.The article about the compound:H-Trp-OMe.HClcas:7524-52-9,SMILESS:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl).Application of 7524-52-9. Through the article, more information about this compound (cas:7524-52-9) is conveyed.

In this research work, we have designed and synthesized a novel Tryptophan-Quinoline conjugated turn-off chemosensor 4 (I) for the selective detection of Fe2+ ion with high sensitivity (3.06 μM) among 21 metal cations such as Ag+, Ca+, Cs+, Cu+, K+, Na+, NH+4, Ba2+, Ca2+, Cd2+, Co2+, Cu2+, Mn2+, Ni2+, Pb2+, Zn2+, Al3+, Au3+, Cr3+ and Fe3+ in DMF-HEPES (1 mM, pH = 7.0, 1:1, volume/volume) aqueous-organic solvent system. It showed a fluorescence quenching mechanism through the blocked PET process. The optical properties, binding mode of the metal ion with the receptor, plausible electron transfer mechanism, and its practical applications have been discussed. This work will open up a new avenue in amino acid-based Fe2+ ion sensors.

As far as I know, this compound(7524-52-9)Application of 7524-52-9 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Organometallic AlaM reagents for umpolung peptide diversification.SDS of cas: 7524-52-9.

Selective modification of peptides and proteins is emerging as a promising strategy to develop novel mechanistic probes and prepare compounds with translational potential. While many methods to perform direct bioconjugation rely on reactions with dehydroalanine, an alternative strategy capitalizing on polarity reversal at the β carbon in amino acids can open access to a new type of diversification reactions characterized by absolute control of regio- and stereoselectivity. Here, we report that alanine carbastannatranes AlaSn can serve as a universal synthon in various C-C and C-heteroatom bond-forming reactions demonstrated in over 50 diverse examples. These reagents are compatible with peptide and protein manipulation techniques and undergo chemoselective conjugation in minutes when promoted by Pd(0). Despite their increased nucleophilicity and propensity to transfer the alkyl group, AlaSn operate at room temperature under buffered conditions (pH 6.5-8.5). We also show that AlaSn can be easily transformed into several canonical L- and D-amino acids in arylation, acylation, and etherification reactions. Furthermore, AlaSn can partake in macrocyclizations exemplified by the synthesis of medium size cyclic peptides with various topologies (7-13 membered macrocycles). Taken together, metalated alanine AlaSn demonstrate unparalleled scope and represent a new type of umpolung reagents suitable for structure-activity relationship studies and peptide diversification.

In some applications, this compound(7524-52-9)SDS of cas: 7524-52-9 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Zeng, Huiying; Wang, Zemin; Li, Chao-Jun published an article about the compound: H-Trp-OMe.HCl( cas:7524-52-9,SMILESS:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl ).Recommanded Product: 7524-52-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:7524-52-9) through the article.

Transition metal catalyzed C-H functionalizations was developed as powerful methods for C-C bond formations. Directing groups, removable directing groups, traceless directing groups, and transient directing groups (TDGs) were successfully used to improve the reaction efficiencies. For the development of greener and more sustainable methods, C-H functionalization using a TDG that also serves as a reagent in aqueous solvent was investigated. The palladium-catalyzed C-H functionalization of tryptamine derivatives using ketones in water successfully generated tetrahydro-β-carbolines with a quaternary carbon center at C1. Deuterium-labeling experiments were discussed to provide insight into the mechanism. The C2-position of pyridine was also successfully functionalized by this strategy.

In some applications, this compound(7524-52-9)Recommanded Product: 7524-52-9 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: H-Trp-OMe.HCl( cas:7524-52-9 ) is researched.Reference of H-Trp-OMe.HCl.Michigami, Kenichi; Sakaguchi, Tatsuhiko; Takemoto, Yoshiji published the article 《Catalytic dehydrative peptide synthesis with gem-diboronic acids》 about this compound( cas:7524-52-9 ) in ACS Catalysis. Keywords: peptide synthesis coupling steric effect; amidation dehydrative gem diboronic acid catalyst reaction mechanism; diboronic acid catalyst crystal mol structure DFT. Let’s learn more about this compound (cas:7524-52-9).

Alkane-gem-diboronic acids have emerged as versatile organoboron catalysts for dehydrative amidation of α-amino acids. A phenol-substituted multiboron catalyst with a B-C-B structure outperformed simple arylboronic acids in the condensation of α-amino acids with suppressed epimerization of electrophiles. gem-diboronic acid catalysis were compatible with various O, N, and S-functionalized α-amino acids bearing N-protecting groups including common carbamates used in peptide synthesis (Boc, Cbz, Fmoc). Gem-Diboronic acid catalysis were compatible with various O, N, and S-functionalized α-amino acids bearing N-protecting groups including common carbamates used in peptide synthesis (Boc, Cbz, Fmoc). N-trifluoroacetyl protection enabled an unprecedented catalytic dehydrative peptide synthesis at room temperature Preliminary mechanistic studies revealed carboxylate-binding nature of gem-diboronic acids, orthogonal to the activation of carboxylic acids by arylboronic acids. The distinctive reactivity of the gem-diboronic acids would open prospects for mild catalytic peptide condensation.

In some applications, this compound(7524-52-9)Reference of H-Trp-OMe.HCl is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: H-Trp-OMe.HCl(SMILESS: N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl,cas:7524-52-9) is researched.Name: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine. The article 《A fast and direct iodide-catalyzed oxidative 2-selenylation of tryptophan》 in relation to this compound, is published in Chemical Communications (Cambridge, United Kingdom). Let’s take a look at the latest research on this compound (cas:7524-52-9).

A metal-free 2-selenylation of tryptophan derivatives is reported, where the use of iodide as the catalyst and oxone as the oxidant is key to obtain high yields. Various functional groups within the di-selenyl and the indole ring are tolerated, and no racemization is generally observed

In addition to the literature in the link below, there is a lot of literature about this compound(H-Trp-OMe.HCl)Related Products of 7524-52-9, illustrating the importance and wide applicability of this compound(7524-52-9).

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Uyanik, Muhammet; Tanaka, Hiroki; Ishihara, Kazuaki published the article 《I+/TBHP Catalysis For Tandem Oxidative Cyclization To Indolo[2,3-b]quinolines》. Keywords: indoloquinoline preparation chemoselective; indole aniline sulfonamide tandem oxidative cyclization tetrabutylammonium iodide catalyst.They researched the compound: H-Trp-OMe.HCl( cas:7524-52-9 ).HPLC of Formula: 7524-52-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7524-52-9) here.

A chemoselective tandem oxidative cyclization/aromatization of indole derivatives tethered to aniline sulfonamides using catalytic amount of tetrabutylammonium in the presence of tert-Bu hydroperoxide (TBHP) as an oxidant under nearly neutral conditions at room temperature is reported. The corresponding indolo[2,3-b]quinolines were obtained as sulfonate salts, which could be easily isolated in anal. pure form via only a simple filtration of the crude reaction mixture The natural product quinindoline could be easily obtained after basic work-up of the sulfonate salt. Control experiments revealed that both ionic and radical active species could be generated in situ under mild conditions for the corresponding oxidative transformations to proceed in a chemoselective manner.

In addition to the literature in the link below, there is a lot of literature about this compound(H-Trp-OMe.HCl)HPLC of Formula: 7524-52-9, illustrating the importance and wide applicability of this compound(7524-52-9).

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem