Category: 7524-52-9

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Convenient method for the synthesis of some novel chiral methyl 2-(2-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)propanoate derivatives and biological evaluation of their antioxidant, cytotoxic, and molecular docking properties, published in 2021-02-28, which mentions a compound: 7524-52-9, Name is H-Trp-OMe.HCl, Molecular C12H15ClN2O2, Recommanded Product: 7524-52-9.

Ten chiral Me 2-(2-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)propanoate derivatives, e.g. I, have been synthesized from optically pure amino Me phenols and 4-nitrophenyl chloroformate. Synthesized ester derivatives were screened for their in vitro antioxidant activity. Title compounds have exhibited comparable antioxidant activity with ascorbic acid as a standard Further, the in vitro cytotoxicity of these compounds were studied through MTT cell proliferation assay in addition the effect on LDH leakage and NO release. Among the derivatives, I showed extremely best activity and the IC50 value (12.54 ± 0.71μM) is very close to doxorubicin (7.2 ± 0.58μM) as a standard Also, mol. docking studies have been carried out with STAT-3 (PDB ID: 1BG1) and BCL-2 (PDB ID: 4AQ3) proteins against the four active compounds, e.g. I. The binding energies of the tested compounds were in the range of -7.76 to -8.41 kcal/mol, which is very close to doxorubicin (-8.53 kcal/mol) as a standard These mol. docking results are in good agreement with the in vitro studies.

Although many compounds look similar to this compound(7524-52-9)Recommanded Product: 7524-52-9, numerous studies have shown that this compound(SMILES:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Formula: C12H15ClN2O2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Photochemical chemoselective alkylation of tryptophan-containing peptides. Author is Laroche, Benjamin; Tang, Xinjun; Archer, Gaetan; Di Sanza, Riccardo; Melchiorre, Paolo.

We report a photochem. method for the chemoselective radical functionalization of tryptophan (Trp)-containing peptides. The method exploits the photoactivity of an electron donor-acceptor complex generated between the tryptophan unit and pyridinium salts. Irradiation with weak light (390 nm) generates radical intermediates right next to the targeted Trp amino acid, facilitating a proximity-driven radical functionalization. This protocol exhibits high chemoselectivity for Trp residues over other amino acids and tolerates biocompatible conditions.

Although many compounds look similar to this compound(7524-52-9)Formula: C12H15ClN2O2, numerous studies have shown that this compound(SMILES:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Haiqi; Song, Hongjian researched the compound: H-Trp-OMe.HCl( cas:7524-52-9 ).Quality Control of H-Trp-OMe.HCl.They published the article 《Synthesis of Four Optical Isomers of Antiviral Agent NK0209 and Determination of Their Configurations and Activities against a Plant Virus》 about this compound( cas:7524-52-9 ) in Journal of Agricultural and Food Chemistry. Keywords: NK0209 isomer preparation antiviral tobacco mosaic virus antiviral; NK0209; antiviral activity; isomers; spatial configuration; synthesis. We’ll tell you more about this compound (cas:7524-52-9).

Previously, we reported for the first time that harmala alkaloids harmine and tetrahydroharmine exhibit activity against plant viruses, and we developed an analog, designated NK0209, that efficiently prevents and controls plant virus diseases. Here, to investigate the influence of the spatial configuration of NK0209 on its antiviral activities, we synthesized its four optical isomers, determined their configurations, and evaluated their activities against tobacco mosaic virus. All four isomers were significantly more active than ningnanmycin, which is one of the most successful com. antiviral agents, with in vivo inactivation, cure, and protection rates of 57.3±1.9%, 54.2±3.3%, 55.0±4.1% at 500μg/mL. Furthermore, anal. of structure-activity relationships demonstrated for the first time that the spatial conformation of NK0209 is an important determinant of its antiviral activity, and our results provide information about the possible optimum configuration for interaction of this mol. with its target protein.

After consulting a lot of data, we found that this compound(7524-52-9)Quality Control of H-Trp-OMe.HCl can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

SDS of cas: 7524-52-9. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about A facile synthesis of meta- and para-terphenylglyoxamide-based peptidomimetics. Author is Yu, Tsz Tin; Bhadbhade, Mohan; Kuppusamy, Rajesh; Black, David St. C.; Kumar, Naresh.

A series of meta- and para-terphenylglyoxamide peptidomimetics have been synthesized by the ring-opening of 5-(biphenylyl)-N-acylisatins with alcs., amines and amino acid Me esters. The starting 5-(biphenylyl)isatins were synthesized via the Suzuki-Miyaura coupling reaction in a convenient and efficient manner.

After consulting a lot of data, we found that this compound(7524-52-9)SDS of cas: 7524-52-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, International Immunopharmacology called The indole-hydantoin derivative exhibits anti-inflammatory activity by preventing the transactivation of NF-κB through the inhibition of NF-κB p65 phosphorylation at Ser276, Author is Lin, Xin; Tago, Kenji; Okazaki, Nozomi; So, Takanori; Takahashi, Kyoko; Mashino, Tadahiko; Tamura, Hiroomi; Funakoshi-Tago, Megumi, which mentions a compound: 7524-52-9, SMILESS is N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl, Molecular C12H15ClN2O2, Synthetic Route of C12H15ClN2O2.

Indole- and hydantoin-based derivatives both exhibit anti-inflammatory activity, suggesting that the structures of indole and hydantoin are functional for this activity. In the present study, we synthesized two types of indole-hydantoin derivatives, IH-1 (5-(1H-indole-3-ylmethylene) imidazolidine-2,4-dione) and IH-2 (5-(1H-indole-3-ylmethyl) imidazolidine-2,4-dione) and examined their effects on LPS-induced inflammatory responses in murine macrophage-like RAW264.7 cells. LPS-induced inflammatory responses were not affected by indole, hydantoin, or IH-2. In contrast, IH-1 significantly inhibited the LPS-induced production of nitric oxide (NO) and secretion of CCL2 and CXCL1 by suppressing the mRNA expression of inducible NO synthase (iNOS), CCL2, and CXCL1. IH-1 markedly inhibited the LPS-induced activation of NF-κB without affecting the degradation of IκBα or nuclear translocation of NF-κB. IH-1 markedly attenuated the transcriptional activity of NF-κB by suppressing the LPS-induced phosphorylation of the NF-κB p65 subunit at Ser276. Furthermore, IH-1 prevented the LPS-induced interaction of NF-κB p65 subunit with a transcriptional coactivator, cAMP response element-binding protein (CBP). Collectively, these results revealed the potential of the novel indole-hydantoin derivative, IH-1 as an anti-inflammatory drug.

After consulting a lot of data, we found that this compound(7524-52-9)Synthetic Route of C12H15ClN2O2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemistry – A European Journal called N-Cyanation of Primary and Secondary Amines with Cyanobenziodoxolone (CBX) Reagent, Author is Chen, Zimin; Yuan, Weiming, which mentions a compound: 7524-52-9, SMILESS is N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl, Molecular C12H15ClN2O2, Recommanded Product: H-Trp-OMe.HCl.

An efficient electrophilic N-cyanation of amines e.g., pyrrolidine with a stable and less-toxic 1-cyano-1,2-benziodoxol-3-(1H)-one reagent towards the synthesis of cyanamides e.g., Pyrrolidine-1-carbonitrile was disclosed. This synthetically practicable strategy allows the construction of a wide variety of cyanamides under very mild and simple conditions with a broad functional group compatibility, and showcases a huge potential in late-stage modification of complex mols.

Although many compounds look similar to this compound(7524-52-9)Recommanded Product: H-Trp-OMe.HCl, numerous studies have shown that this compound(SMILES:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application In Synthesis of H-Trp-OMe.HCl. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Construction of thioamide peptide via sulfur-involved amino acids/amino aldehydes coupling. Author is Liao, Yanyan; Jiang, Xuefeng.

A sulfur-involved ligation for thioamide quasi-peptides was developed via amino acids and amino aldehydes coupling. The key to the transformation was the chelation of copper with imines for chiral activation and fixation. In this environment, linear polysulfur decreased the alkalinity of single sulfur anions to prevent racemization caused by the interaction between sulfur and sodium sulfide. Dipeptides, tripeptides, tetrapeptides, and the linkage between the drug and amino acids were successfully obtained.

Although many compounds look similar to this compound(7524-52-9)Application In Synthesis of H-Trp-OMe.HCl, numerous studies have shown that this compound(SMILES:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Convenient method for the synthesis of some novel chiral methyl 2-(2-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)propanoate derivatives and biological evaluation of their antioxidant, cytotoxic, and molecular docking properties, published in 2021-02-28, which mentions a compound: 7524-52-9, Name is H-Trp-OMe.HCl, Molecular C12H15ClN2O2, Recommanded Product: 7524-52-9.

Ten chiral Me 2-(2-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)propanoate derivatives, e.g. I, have been synthesized from optically pure amino Me phenols and 4-nitrophenyl chloroformate. Synthesized ester derivatives were screened for their in vitro antioxidant activity. Title compounds have exhibited comparable antioxidant activity with ascorbic acid as a standard Further, the in vitro cytotoxicity of these compounds were studied through MTT cell proliferation assay in addition the effect on LDH leakage and NO release. Among the derivatives, I showed extremely best activity and the IC50 value (12.54 ± 0.71μM) is very close to doxorubicin (7.2 ± 0.58μM) as a standard Also, mol. docking studies have been carried out with STAT-3 (PDB ID: 1BG1) and BCL-2 (PDB ID: 4AQ3) proteins against the four active compounds, e.g. I. The binding energies of the tested compounds were in the range of -7.76 to -8.41 kcal/mol, which is very close to doxorubicin (-8.53 kcal/mol) as a standard These mol. docking results are in good agreement with the in vitro studies.

Although many compounds look similar to this compound(7524-52-9)Recommanded Product: 7524-52-9, numerous studies have shown that this compound(SMILES:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Formula: C12H15ClN2O2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Photochemical chemoselective alkylation of tryptophan-containing peptides. Author is Laroche, Benjamin; Tang, Xinjun; Archer, Gaetan; Di Sanza, Riccardo; Melchiorre, Paolo.

We report a photochem. method for the chemoselective radical functionalization of tryptophan (Trp)-containing peptides. The method exploits the photoactivity of an electron donor-acceptor complex generated between the tryptophan unit and pyridinium salts. Irradiation with weak light (390 nm) generates radical intermediates right next to the targeted Trp amino acid, facilitating a proximity-driven radical functionalization. This protocol exhibits high chemoselectivity for Trp residues over other amino acids and tolerates biocompatible conditions.

Although many compounds look similar to this compound(7524-52-9)Formula: C12H15ClN2O2, numerous studies have shown that this compound(SMILES:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Haiqi; Song, Hongjian researched the compound: H-Trp-OMe.HCl( cas:7524-52-9 ).Quality Control of H-Trp-OMe.HCl.They published the article 《Synthesis of Four Optical Isomers of Antiviral Agent NK0209 and Determination of Their Configurations and Activities against a Plant Virus》 about this compound( cas:7524-52-9 ) in Journal of Agricultural and Food Chemistry. Keywords: NK0209 isomer preparation antiviral tobacco mosaic virus antiviral; NK0209; antiviral activity; isomers; spatial configuration; synthesis. We’ll tell you more about this compound (cas:7524-52-9).

Previously, we reported for the first time that harmala alkaloids harmine and tetrahydroharmine exhibit activity against plant viruses, and we developed an analog, designated NK0209, that efficiently prevents and controls plant virus diseases. Here, to investigate the influence of the spatial configuration of NK0209 on its antiviral activities, we synthesized its four optical isomers, determined their configurations, and evaluated their activities against tobacco mosaic virus. All four isomers were significantly more active than ningnanmycin, which is one of the most successful com. antiviral agents, with in vivo inactivation, cure, and protection rates of 57.3±1.9%, 54.2±3.3%, 55.0±4.1% at 500μg/mL. Furthermore, anal. of structure-activity relationships demonstrated for the first time that the spatial conformation of NK0209 is an important determinant of its antiviral activity, and our results provide information about the possible optimum configuration for interaction of this mol. with its target protein.

After consulting a lot of data, we found that this compound(7524-52-9)Quality Control of H-Trp-OMe.HCl can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem