Category: 707-61-9

Quality Control of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Synthesis of some 1-aryl-2,3-dibromophospholanes as novel anti-cancer agents. Author is Yamada, Manabu; Asai, Kazuhide; Yamashita, Junko; Suyama, Takuya; Niimi, Taishi; Maddali, Kasthuraiah; Fujie, Michio; Nakamura, Satoki; Kimura, Motohiko; Tanaka, Yasutaka; Toda, Mitsuo; Yamashita, Mitsuji.

Novel phosphorus heterocyclic compounds, 3-methyl-1-(3-bromophenyl as well as some 3-substituted phenyl)-2-phospholene 1-oxides, were synthesized from 1-phenyl-2-phospholene 1-oxide via 3-methyl-1-(3-nitrophenyl)-2-phospholene 1-oxide. 1-(4-Bromophenyl)-2-phospholene was prepared by Grignard coupling reaction of 1-chloro-3-methyl-2-phospholene 1-oxide with 4-bromophenylmagnesium bromide. 2,3-Dibromo-3-methyl-1-arylphospholane 1-oxides were prepared by the addition reaction of bromine to the C=C double bond of 2-phospholenes. The substituent effect of the Ph group of the 1-aryl-phospholanes on the observed anti-proliferative effect against U937 leukemia cell lines evaluated by MTT in vitro methods showed that 2,3-dibromo-3-methyl-1-(4-bromophenyl)phospholane was the most active among 1-arylphospholanes. These novel dibromophosphorus heterocyclic derivatives exhibit much higher anticancer activity than Gleevec (mol. targeting chemotherapeutic agent) against U937 cells.

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Zhou, Zhenhua published the article 《A chiral shift reagent for measurement of optical purities of chiral phosphine oxides》. Keywords: phosphine oxide optical purity determination; NMR phosphine oxide optical purity determination; phenylmethylphospholene optical purity determination; phospholene methylphenyl optical purity determination; nitrobenzoylphenylethylamine chiral shift reagent NMR.They researched the compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide( cas:707-61-9 ).HPLC of Formula: 707-61-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:707-61-9) here.

(R)-(-)-N-(3,5-Dinitrobenzyl)-α-phenylethylamine (I) is an excellent chiral shift reagent for measurement of optical purities of chiral phosphine oxides. The method of preparation and application of reagent I are discussed in detail. 1-Phenyl-3-methyl-2-phospholene(II) is oxidized to 1-phenyl-3-methyl-2-phospholene 1-oxide (III) which is then reacted with tert-BuOOH with complete retention of optical activity. When phosphine oxide is mixed with reagent(I), optical purity of phosphine oxide can be measured according to 1H NMR spectra; the optical purity of II can be determined

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Mochizuki, Amane; Takeshi, Kazumasa; Haba, Osamu; Kato, Sadao; Ueda, Mitsuru published the article 《Synthesis of photosensitive polycarbodiimide》. Keywords: photosensitive polycarbodiimide preparation toluene diisocyanate polymerization; neg working photosensitive dimethoxynitrobenzyloxycarbonyl methylpiperidine film; photoamine generator TDI polymer film photolithog; photolysis dimethoxynitrobenzyloxycarbonyl methylpiperidine.They researched the compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide( cas:707-61-9 ).Reference of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:707-61-9) here.

A neg.-working photosensitive polymer based on polycarbodiimide (PCD) and {[(4,5-dimethoxy-2-nitrobenzyl)oxy]carbonyl}-2-methylpiperidine (I) as a photoamine generator(PAG) has been developed. The end-capped PCDs with number average mol. weights of 1500 and 2500 were prepared by polycondensation of tolylene 2,4-diisocyanate (TDI) in the presence of m-tolyl isocyanate and 3-methyl-1-phenyl-2-phospholene-1-oxide as an end-capping agent and a catalyst, resp. PCDs were amorphous and soluble in common organic solvents, such as toluene, chloroform, and cyclohexanone. Thermogravimetry of the polymers showed good thermal stability, indicating that a 10% weight loss of the polymers was at 480° in nitrogen. The PCD films were transparent above 360 nm. The PCD containing I showed a sensitivity of 225 mJ/cm2 and a contrast of 1.5, when it was post-baked at 90°C sec, followed by development with toluene at 25°C.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Research and development of phospha sugar anti-cancer agents with anti-leukemic activity, the main research direction is phenylphospholene phospha sugar analog preparation antileukemic activity.Name: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide.

We have synthesized three deoxybromophospha sugar analogs, 4-bromo-3-methyl-1-phenyl-2-phospholene 1-oxide (MBMPP (2)), 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide (DBMPP (3)), the 2,3,4-tribromo-3-methyl-1-phenylphospholane 1-oxide (TBMPP (4)), by the reaction of 3-methyl-1-phenyl-2-phospholene 1-oxide (1b) and/or 2 with bromine, and investigated their potentials as anti-leukemic agents against human leukemia cell lines of K562 and U937. Cells’ growth inhibition was determined by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) in vitro assay. All agents showed inhibitory effects on leukemia cell proliferation, indicating that inhibition appeared to be dependent on number of bromine substituent in the heterocyclic structure. Further, the phospha sugar derivatives did not show any inhibitory effects on normal cell proliferation. These agents may facilitate the development of new strategies in mol. targeting anti-leukemic therapy.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Novel synthesis and structure of phosphanyl sugar derivatives, published in 1997-07-31, which mentions a compound: 707-61-9, Name is 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, Molecular C11H13OP, Category: dioxole.

Some phosphanyl sugars, e.g. I, which are analogs of sugars having a phosphorus atom in place of the ring oxygen, were synthesized from 2- and 3-phospholenes as starting materials. Catalytic cis-dihydroxylation of 2-phospholene or 3-phospholene 1-oxide derivatives with osmium(VIII) oxide in the presence of a Co-oxidant afforded 3-deoxy- or 1-deoxy-tetrofuranose-type phosphanyl sugar derivatives, resp. Cis-Dihydroxylation of 4-acyloxy-2-phospholene 1-oxide derivatives gave tetrofuranose type phosphanyl sugar derivatives Some of these derivatives of phosphanyl sugars were subjected to structural analyses using 1H NMR and X-ray crystallog.

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1,3-Benzodioxole – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Improved syntheses and characterization of the isomers of 3-methyl-1-phenylphospholene 1-oxide, the main research direction is phospholene oxide isomer; NMR phospholene oxide; IR phospholene oxide; Raman laser phospholene oxide; mass spectra phospholene oxide.Recommanded Product: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide.

Isomerically pure 3-methyl-1-phenyl-2-phospholene 1-oxide and 3-methyl-1-phenyl-3-phospholene 1-oxide were prepared and characterized by 1H (60 and 270 MHz), 31P and 13C NMR, IR, Laser Raman, and mass spectrometry. 1,4-Cycloaddition of isoprene and PhPCl2 after hydrolysis of the addition product, yielded a mixture of the above 2-isomer and small amounts of 3-isomer from which pure 2-isomer was separated by fractional crystallization The analog reaction with PhPBr2 gave isomerically pure 3-isomer. An improved and shortened work-up procedure for the phospholene oxides was used resulting in higher yields.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Asian Journal of Organic Chemistry called Synthesis of Multifunctional Alkenes from Substituted Acrylates and Aldehydes via Phosphine-Catalyzed Wittig Reaction, Author is Tsai, Yi-Ling; Lin, Wenwei, which mentions a compound: 707-61-9, SMILESS is CC1=CP(CC1)(C2=CC=CC=C2)=O, Molecular C11H13OP, Electric Literature of C11H13OP.

An efficient synthesis of multifunctional alkenes (E)-R1C(O)CH2C(CO2Et):CHR2 (R1 = Me, Ph, 4-O2NC6H4, 2-thienyl, 2-naphthyl, etc.; R2 = Ph, 3-O2NC6H4, 2-furyl, 4-pyridinyl, etc.) starting from substituted acrylates (E)-R1C(O)CH:CHCO2Et and aldehydes R2CHO has been developed via phosphine-catalyzed Wittig reactions. The reactions proceed smoothly even under mild conditions (30-60 °C) via a phosphine/phosphine oxide catalytic cycle using phenylsilane as the reducing agent. According to this simple protocol, the desired products are obtained in moderate to excellent yields as single stereoisomers.

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Recommanded Product: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Preparation and characterization of phospholanes and phospha sugars as novel anti-cancer agents. Author is Ito, Satoru; Yamashita, Mitsuji; Niimi, Taishi; Fujie, Michio; Reddy, Valluru Krishna; Totsuka, Hirono; Haritha, Buchammagari; Maddali, Kasthuraiah; Nakamura, Satoki; Asai, Kazuhide; Suyama, Takuya; Yamashita, Junko; Iguchi, Yukiko; Yu, Gang; Oshikawa, Tatsuo.

Diastereo isomeric erythro and threo forms of 2,3-epoxy-1-phenylphospholane 1-oxides were synthesized from threo and erythro forms of 2-bromo-3-hydroxy-1-phenylphospholane 1-oxides being prepared from 1-phenyl-2-phospholene 1-oxide. Alternatively, the epoxides were also prepared by the epoxidation of the 2-phospholene with peroxides such as sodium peroxide and hydrogen peroxide. The reactivity and regioselectivity for the reaction of erythro and threo forms of the 2,3-epoxides with nucleophiles were investigated by using amines, and the reaction afforded 2-amino-3-hydroxy-1-phenylphospholane 1-oxides, which correspond to phospha sugar N-glycosides. 2,3-Dibromo-3-methyl-1-phenylphospholane 1-oxides were first prepared from 3-methyl-1-phenyl-2-phospholene 1-oxide. The prepared phospholanes or phospha sugars were biol. qualified by MTT (3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide) in vitro method to find that some of these phosphorus heterocycles or phospha sugars have quite efficient anti-cancer activity for leukemia cells in manners of (i) wide spectra, (ii) high activities, and (iii) high specificities.

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Product Details of 707-61-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Preparation and characterization of novel 4-bromo-3,4-dimethyl-1-phenyl-2-phospholene 1-oxide and the analogous phosphorus heterocycles or phospha sugars. Author is Yamada, Manabu; Yamashita, Mitsuji; Suyama, Takuya; Yamashita, Junko; Asai, Kazuhide; Niimi, Taishi; Ozaki, Nobuhisa; Fujie, Michio; Maddali, Kasthuraiah; Nakamura, Satoki; Ohnishi, Kazunori.

4-Bromo-3,4-dimethyl-1-phenyl-2-phospholene 1-oxide (3c) was 1st synthesized from 3,4-dimethyl-1-phenyl-2-phospholene 1-oxide (2c) by a bromo-radical substitution reaction occurred at C-4 position by N-bromosuccinimide and 2,2′-azobisisobutyronitrile. The novel phospha sugar analog 3c exerted high anti-proliferative effect on U937 cells evaluated by MTT in vitro methods and was much more efficient than that of Gleevec, which is known as a mol. targeting chemotherapeutical agent. The substitution of 2-phospholenes at C-3 and C-4 position with Me groups as well as 4-bromo substituent suggests a good anti-proliferative effect.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yamashita, Mitsuji; Yabui, Akihiro; Suzuki, Kazumitsu; Kato, Yukihiro; Uchimura, Miyuki; Iida, Akihito; Mizuno, Hiroyuki; Ikai, Koichi; Oshikawa, Tatsuo; Parkanayi, Laszlo; Clardy, Jon researched the compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide( cas:707-61-9 ).Category: dioxole.They published the article 《Novel synthesis and structure of phosphanyl sugar derivatives》 about this compound( cas:707-61-9 ) in Journal of Carbohydrate Chemistry. Keywords: phospholene conversion phosphanyl monosaccharide; phosphanyl monosaccharide preparation mol structure. We’ll tell you more about this compound (cas:707-61-9).

Some phosphanyl sugars, e.g. I, which are analogs of sugars having a phosphorus atom in place of the ring oxygen, were synthesized from 2- and 3-phospholenes as starting materials. Catalytic cis-dihydroxylation of 2-phospholene or 3-phospholene 1-oxide derivatives with osmium(VIII) oxide in the presence of a Co-oxidant afforded 3-deoxy- or 1-deoxy-tetrofuranose-type phosphanyl sugar derivatives, resp. Cis-Dihydroxylation of 4-acyloxy-2-phospholene 1-oxide derivatives gave tetrofuranose type phosphanyl sugar derivatives Some of these derivatives of phosphanyl sugars were subjected to structural analyses using 1H NMR and X-ray crystallog.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem