Category: 68527-74-2

Sipes, I. G. published the artcileHydroxy- and alkoxy-substituted benzyl derivatives (addendum), Quality Control of 68527-74-2, the publication is WHO Food Additives Series (2009), 533-548, database is CAplus.

A review discusses the assessment of dietary exposure, absorption, distribution, metabolism, and safety of hydroxy- and alkoxy-substituted benzyl derivatives for use as flavoring agents. The acute toxicity, genotoxicity, and reproductive/developmental toxicity of these flavoring agents are also tackled.

WHO Food Additives Series published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C12H9NO, Quality Control of 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Ween, M. P. published the artcileE-cigarettes and health risks: more to the flavor than just the name, Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, the publication is American Journal of Physiology (2021), 320(4), L600-L614, database is CAplus and MEDLINE.

The growing interest in regulating flavored E-liquids must incorporate understanding of the “flavoring profile” of each E-liquid-which flavorings (flavoring chems.) are present and at what concentrations not just focusing on the flavor on the label. We investigated the flavoring profile of 10 different flavored E-liquids We assessed bronchial epithelial cell viability and apoptosis, phagocytosis of bacteria and apoptotic cells by macrophages after exposure to E-cigarette vapor extract (EVE). We validated our data in normal human bronchial epithelial cells (NHBE) and alveolar macrophages (AM) from healthy donors. We also assessed cytokine release and validated in the saliva from E-cigarette users. Increased necrosis/apoptosis (16.1-64.5% apoptosis) in 16HBE cells was flavor dependent, and NHBEs showed an increased susceptibility to flavors. In THP-1 differentiated macrophages phagocytosis was also flavor dependent, with AM also showing increased susceptibility to flavors. Further, Banana and Chocolate were shown to reduce surface expression of phagocytic target recognition receptors on alveolar macrophages. Banana and Chocolate increased IL-8 secretion by NHBE, whereas all 4 flavors reduced AM IL-1β secretion, which was also reduced in the saliva of E-cigarette users compared with healthy controls. Flavorant profiles of E-liquids varied from simple 2 compound mixtures to complex mixtures containing over a dozen flavorants. E-liquids with high benzene content, complex flavoring profiles, high chem. concentration had the greatest impacts. The Flavorant profile of E-liquids is key to disruption of the airway status quo by increasing bronchial epithelial cell apoptosis, causing alveolar macrophage phagocytic dysfunction, and altering airway cytokines.

American Journal of Physiology published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C5H5NO3S, Name: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Beresnevich, L. B. published the artcileSynthesis of 1,3-dioxolanes from natural carbonyl compounds, Computed Properties of 68527-74-2, the publication is Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk (2009), 73-76, database is CAplus.

Condensation of various naturally occurring aldehydes and ketones R¹R²CO [R¹ = H, R² = n-Pr, i-Bu, 4-MeC₆H₄CH₂CHMe, 4-HO-3-MeOC₆H₃, etc.; R¹R² = (CH₂)₄, (CH₂)₅, etc.; R¹ = R² = n-Pr; R¹ = Me, R² = Et, t-Bu, n-hexyl] with 1,2-propanediol in the presence of sulfonated cationite FIBAN K-1 neat or in benzene gave the corresponding 1,3-dioxolanes in 50-98% yields.

Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Computed Properties of 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Jiang, Wei-hua published the artcileSynthesis of vanillin 1,2-propylene glycol acetal catalyzed by H₃PMo₁₂O₄₀, Recommanded Product: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, the publication is Huaxue Shiji (2009), 31(6), 457-460, database is CAplus.

A method for the synthesis of the title compound [i.e., 2-methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, vanillin 1,2-propylene glycol acetal] is reported here. Vanillin 1,2-propylene glycol acetal was synthesized from vanillin [i.e., 4-hydroxy-3-methoxybenzaldehyde] and 1,2-propylene glycol using H₃PMo₁₂O₄₀ as the catalyst. Factors influencing the product formation, such as molar ratio of reactants, time, catalyst type and amount, and different water entrainment agents, were studied and optimized reaction conditions were determined Reaction conditions were found as follows: molar ratio of aldehyde/glycol = 1.0/1.3, catalyst dosage of 0.3%, a cyclohexane amount of 15 mL, and a reaction time of 4.5 h. The selectivity was above 98% and the product yield was 94.58%. The product structure was determined by IR, GC, NMR.

Huaxue Shiji published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Recommanded Product: 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Liu, Fei published the artcileSynthesis of vanillin propylene glycol acetal catalyzed by solid superacid, Synthetic Route of 68527-74-2, the publication is Jingxi Huagong (2010), 27(2), 155-159, database is CAplus.

The synthesis of vanillin propylene glycol acetal catalyzed by solid superacid was investigated. A series of solid superacids were prepared and used to synthesize vanillin propylene glycol acetal. Solid superacids excelled phosphoric acid and citric acid, and SO₄^2-/ZrO₂ was the best catalyst. The optimum conditions using SO₄^2-/ZrO₂ were as follows: when vanillin was 0.05 mol, n(vanillin):n(1,2-propylene glycol)=1:2.4, the water-carrying agent was toluene (20 mL); the amount of catalyst was 0.25% of the weight of vanillin; and the reaction time 1.0 h. Under these conditions, the yield of vanillin propylene glycol acetal was 95.1%. The total yield was 90.5% and the relative mass fraction was 99.5% after vacuum distillation The structure of the product was identified by IR and GC-MS. The yield could still achieve 91.1% when the catalyst was calcined 20 days later. The reaction time was short and the catalyst was efficient and stable. The post-processing was simple in this process.

Jingxi Huagong published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Synthetic Route of 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Liu, Fei published the artcileSynthesis of vanillin propylene glycol acetal catalyzed by solid superacid, Synthetic Route of 68527-74-2, the publication is Jingxi Huagong (2010), 27(2), 155-159, database is CAplus.

The synthesis of vanillin propylene glycol acetal catalyzed by solid superacid was investigated. A series of solid superacids were prepared and used to synthesize vanillin propylene glycol acetal. Solid superacids excelled phosphoric acid and citric acid, and SO₄^2-/ZrO₂ was the best catalyst. The optimum conditions using SO₄^2-/ZrO₂ were as follows: when vanillin was 0.05 mol, n(vanillin):n(1,2-propylene glycol)=1:2.4, the water-carrying agent was toluene (20 mL); the amount of catalyst was 0.25% of the weight of vanillin; and the reaction time 1.0 h. Under these conditions, the yield of vanillin propylene glycol acetal was 95.1%. The total yield was 90.5% and the relative mass fraction was 99.5% after vacuum distillation The structure of the product was identified by IR and GC-MS. The yield could still achieve 91.1% when the catalyst was calcined 20 days later. The reaction time was short and the catalyst was efficient and stable. The post-processing was simple in this process.

Jingxi Huagong published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Synthetic Route of 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem