Category: 68527-74-2

Synthesis of vanillin 1,2-propylene glycol acetal catalyzed by iodine was written by Wang, Yong-lan;Bo, Hui-ying;Wang, Hong-she. And the article was included in Huaxue Gongchengshi in 2013.COA of Formula: C11H14O4 This article mentions the following:

Vanillin 1,2-propylene glycol acetal was synthesized through the condensation of vanillin with 1,2-propylene glycol using iodine as a catalyst. The effects of the molar ratio of reactant, the amount of catalyst, reaction temperature and reaction time on the yield of product were discussed. The results showed that the optimized reaction conditions are as follows: the molar ratio of vanillin (0.1 mol) to 1,2-propylene glycol (0.18 mol) is 1 : 1.8; the amount of catalyst is 1.2 g, reaction temperature is 60°C and the reaction time is 20 min. Under the optimum conditions mentioned above, the yield of vanillin 1,2-propylene glycol acetal reached more than 91.3%. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2COA of Formula: C11H14O4).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.COA of Formula: C11H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Mass spectrometry of the acetal derivatives of selected generally recognized as safe listed aldehydes with ethanol, 1,2-propylene glycol and glycerol was written by Woelfel, Keith;Hartman, Thomas G.. And the article was included in ACS Symposium Series in 1998.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol This article mentions the following:

The FEMA-GRAS list offers flavor chemists a repertoire of nearly 2000 chems. for use in compounding natural and synthetic flavors for the U.S. marketplace. Aldehydes constitute an important class of these potential flavorants and are widely utilized to impart specific nuances. Alcs. such as ethanol, 1,2-propylene glycol and glycerol are commonly employed as solvents in compounded flavor systems due to their low odor and miscibility in a wide range of aqueous and organic matrixes. However, alcs. and aldehydes react rapidly under anhydrous conditions to form acetal derivatives which often possess different sensory properties. This well known reaction is reversible and its equilibrium is influenced by time, temperature, pH and moisture content. Mass spectra of acetals are currently under represented in com. databases and few literature references are available. Our investigation involved a systematic mass spectrometric study of the acetal derivatives of selected GRAS aldehydes reacted with ethanol, 1,2-propylene glycol and glycerol. Aldehydes from different chem. classes representing saturated and unsaturated aliphatics, aromatics, heterocyclics, terpenoids and others were included for characterization. The corresponding acetals were synthesized, analyzed by GC-MS in electron ionization mode and their retention indexes on a non-polar (polydimethylsiloxane) capillary column were determined A database of mass spectra was produced which includes many previously unreported species. In total, over 60 individual mass spectra were recorded. The characteristic mass spectral fragmentation pathways for each class of acetal are described. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

E-cigarettes and health risks: more to the flavor than just the name was written by Ween, M. P.;Moshensky, A.;Thredgold, L.;Bastian, N. A.;Hamon, R.;Badiei, A.;Nguyen, P. T.;Herewane, K.;Jersmann, H.;Bojanowski, C. M.;Shin, J.;Reynolds, P. N.;Alexander, L. E. Crotty;Hodgeelom, S. J.. And the article was included in American Journal of Physiology in 2021.Reference of 68527-74-2 This article mentions the following:

The growing interest in regulating flavored E-liquids must incorporate understanding of the “flavoring profile” of each E-liquid-which flavorings (flavoring chems.) are present and at what concentrations not just focusing on the flavor on the label. We investigated the flavoring profile of 10 different flavored E-liquids We assessed bronchial epithelial cell viability and apoptosis, phagocytosis of bacteria and apoptotic cells by macrophages after exposure to E-cigarette vapor extract (EVE). We validated our data in normal human bronchial epithelial cells (NHBE) and alveolar macrophages (AM) from healthy donors. We also assessed cytokine release and validated in the saliva from E-cigarette users. Increased necrosis/apoptosis (16.1-64.5% apoptosis) in 16HBE cells was flavor dependent, and NHBEs showed an increased susceptibility to flavors. In THP-1 differentiated macrophages phagocytosis was also flavor dependent, with AM also showing increased susceptibility to flavors. Further, Banana and Chocolate were shown to reduce surface expression of phagocytic target recognition receptors on alveolar macrophages. Banana and Chocolate increased IL-8 secretion by NHBE, whereas all 4 flavors reduced AM IL-1β secretion, which was also reduced in the saliva of E-cigarette users compared with healthy controls. Flavorant profiles of E-liquids varied from simple 2 compound mixtures to complex mixtures containing over a dozen flavorants. E-liquids with high benzene content, complex flavoring profiles, high chem. concentration had the greatest impacts. The Flavorant profile of E-liquids is key to disruption of the airway status quo by increasing bronchial epithelial cell apoptosis, causing alveolar macrophage phagocytic dysfunction, and altering airway cytokines. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Reference of 68527-74-2).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 68527-74-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of 1,3-dioxolanes from natural carbonyl compounds was written by Beresnevich, L. B.;Moiseichuk, K. L.. And the article was included in Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk in 2009.Product Details of 68527-74-2 This article mentions the following:

Condensation of various naturally occurring aldehydes and ketones R¹R²CO [R¹ = H, R² = n-Pr, i-Bu, 4-MeC₆H₄CH₂CHMe, 4-HO-3-MeOC₆H₃, etc.; R¹R² = (CH₂)₄, (CH₂)₅, etc.; R¹ = R² = n-Pr; R¹ = Me, R² = Et, t-Bu, n-hexyl] with 1,2-propanediol in the presence of sulfonated cationite FIBAN K-1 neat or in benzene gave the corresponding 1,3-dioxolanes in 50-98% yields. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Product Details of 68527-74-2).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Product Details of 68527-74-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of vanillin 1,2-propylene glycol acetal catalyzed by silica supported ferric sulfate was written by Tu, Yuan-hong;Xiong, Bin;Liao, Wei-lin;Xu, Zhao-hui. And the article was included in Riyong Huaxue Gongye in 2008.Recommanded Product: 68527-74-2 This article mentions the following:

Vanillin 1,2-propylene glycol acetal was synthesized using 1,2 -propylene glycol and vanillin as starting materials and silica supported ferric sulfate as catalyst. Effects of factors on yield of product, such as molar ratio of the reactants, reaction time, catalyst dosage and its stability, were investigated. Exptl. results showed that the preferential conditions were as follows: based on 0.1 mol of vanillin, the molar ratio of vanillin to 1,2 -propylene glycol was 1.0: 1.4; the dosage of catalyst was 2.5% of the total weight of the reactants; the amount of cyclohexane as water stripping agent was 12 mL; the reaction time was 3.0 h; under these conditions, the yield could achieve 86.0%. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Recommanded Product: 68527-74-2).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 68527-74-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of vanillin 1,2-propylene glycol acetal by phosphomolybdic acid was written by Jin, Lie;Zhou, Tong-wu. And the article was included in Huaxue Gongchengshi in 2010.Category: dioxole This article mentions the following:

Vanillin 1,2-propylene glycol acetal was synthesized from vanillin and 1,2-propylene glycol using H₃PO₃-MoO₃-xH₂O as the catalyst. Factors influencing the yield, such as the molar ratio of starting materials, time, catalyst species and amount, and different water entraining agents, were studied and the better reaction conditions were determined The factors influencing the synthesis were studied and the optimal reaction conditions were found as follows: a molar ratio of cinnamaldehyde/ethylene glycol = 1.0/1.3, a catalyst dosage of 0.3%, a cyclohexane amount of 15 mL and a reaction time of 4.5 h. The selectivity was above 98% and the product yield was 94.58%. The structure of vanillin 1,2-propylene glycol acetal was identified by means of IR and GC. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Category: dioxole).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of vanillin 1,2-propylene glycol acetal catalyzed by iodine was written by Wang, Yong-lan;Bo, Hui-ying;Wang, Hong-she. And the article was included in Huaxue Gongchengshi in 2013.COA of Formula: C11H14O4 This article mentions the following:

Vanillin 1,2-propylene glycol acetal was synthesized through the condensation of vanillin with 1,2-propylene glycol using iodine as a catalyst. The effects of the molar ratio of reactant, the amount of catalyst, reaction temperature and reaction time on the yield of product were discussed. The results showed that the optimized reaction conditions are as follows: the molar ratio of vanillin (0.1 mol) to 1,2-propylene glycol (0.18 mol) is 1 : 1.8; the amount of catalyst is 1.2 g, reaction temperature is 60°C and the reaction time is 20 min. Under the optimum conditions mentioned above, the yield of vanillin 1,2-propylene glycol acetal reached more than 91.3%. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2COA of Formula: C11H14O4).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.COA of Formula: C11H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Mass spectrometry of the acetal derivatives of selected generally recognized as safe listed aldehydes with ethanol, 1,2-propylene glycol and glycerol was written by Woelfel, Keith;Hartman, Thomas G.. And the article was included in ACS Symposium Series in 1998.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol This article mentions the following:

The FEMA-GRAS list offers flavor chemists a repertoire of nearly 2000 chems. for use in compounding natural and synthetic flavors for the U.S. marketplace. Aldehydes constitute an important class of these potential flavorants and are widely utilized to impart specific nuances. Alcs. such as ethanol, 1,2-propylene glycol and glycerol are commonly employed as solvents in compounded flavor systems due to their low odor and miscibility in a wide range of aqueous and organic matrixes. However, alcs. and aldehydes react rapidly under anhydrous conditions to form acetal derivatives which often possess different sensory properties. This well known reaction is reversible and its equilibrium is influenced by time, temperature, pH and moisture content. Mass spectra of acetals are currently under represented in com. databases and few literature references are available. Our investigation involved a systematic mass spectrometric study of the acetal derivatives of selected GRAS aldehydes reacted with ethanol, 1,2-propylene glycol and glycerol. Aldehydes from different chem. classes representing saturated and unsaturated aliphatics, aromatics, heterocyclics, terpenoids and others were included for characterization. The corresponding acetals were synthesized, analyzed by GC-MS in electron ionization mode and their retention indexes on a non-polar (polydimethylsiloxane) capillary column were determined A database of mass spectra was produced which includes many previously unreported species. In total, over 60 individual mass spectra were recorded. The characteristic mass spectral fragmentation pathways for each class of acetal are described. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem