Rahnama, Golsomeh et al. published their research in Journal of Animal Physiology and Animal Nutrition in 2020 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Oral administration of royal jelly may improve the preservation of rooster spermatozoa was written by Rahnama, Golsomeh;Deldar, Hamid;Ansari Pirsaraei, Zarbakht;Kazemifard, Mohammad. And the article was included in Journal of Animal Physiology and Animal Nutrition in 2020.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

The aim of the present study was to investigate the effect of dietary supplementation of royal jelly (RJ) on liquid and frozen storage of rooster spermatozoa. Twenty-five 30-wk-old of Mazandaran native breeder roosters were randomly divided into five treatments (n = 5 roosters/group). Exptl. treatments are designed to include a control group and various levels (0.0 (RJ0), 100 (RJ100), 200 (RJ200), 300 (RJ300) mg kg-1 BW-1) of royal jelly (RJ) that were fed to the roosters using force-feed method. The result of this study showed that the spermatozoa forward progressive motility, abnormality, membrane integrity, and viability were improved by the RJ100 group compared to the other groups after 24 and 48 h storage period at 4°C. The percentage of membrane integrity and forward progressive motility after freeze-thawing in the RJ100 group was significantly higher than the other groups, and the percentage of abnormal spermatozoa was lower. A significant decrease in semen quality parameters was seen after 24 and 48 h of refrigeration, but there was no observed change between 2 and 24 h in the RJ100. Moreover, after freeze-thawing, DNA integrity and mitochondrial activity in the RJ100 group were significantly higher than the other groups. According to our results, feeding of RJ at 100 mg kg-1 BW-1 to the roosters was improved spermatozoa characteristics during liquid and cryopreservation conditions. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Eshtiyaghi, Mahbobeh et al. published their research in Theriogenology in 2016 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application of 6413-10-1

Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization was written by Eshtiyaghi, Mahbobeh;Deldar, Hamid;Pirsaraei, Zarbakht Ansari;Shohreh, Bahram. And the article was included in Theriogenology in 2016.Application of 6413-10-1 The following contents are mentioned in the article:

The aim of this study was to investigate the effect of different concentrations of royal jelly (RJ) on in vitro maturation (IVM), fertilization, cleavage, blastocyst rates, glutathione (GSH) content in ovine oocyte, mRNA abundance of antioxidant enzymes in both oocyte and cumulus, and glucose metabolism-related genes in cumulus cells. In vitro maturation of oocyte was performed in the presence of control (RJ0), 2.5 (RJ2.5), 5 (RJ5), and 10 (RJ10) mg/mL of RJ. Nuclear status, intracellular GSH content in oocytes, and mRNA abundance of selected genes were evaluated following 24 h of IVM. Following the IVM, fertilization and embryo culture were carried out in all the groups and embryonic development was examined The addition of 10-mg/mL RJ to maturation media not only yielded a higher number of oocytes at MII stage but also showed an increased level of intracellular GSH content than did RJ2.5 and control groups. Fertilization, cleavage, and blastocyst rate were higher in the RJ10 treatment group in comparison to the control one. In cumulus cells, the expression of PFKM, PFKL, and G6PDH were increased following the addition of RJ to the maturation media. Supplementation of 10-mg/mL RJ to IVM medium increased the GPx mRNA abundance in both oocyte and cumulus cells and SOD expression in the cumulus cells. The CAT mRNA abundance was not influenced by the addition of RJ to the maturation media in either oocyte or cumulus cells. It seems that the improvement of oocyte maturation and its subsequent development in RJ10 group may be associated with amelioration of redox status in the oocytes and activation of glucose metabolic pathways in their surrounding cumulus cells. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Application of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Lu, Haotian et al. published their research in Journal of Materials Chemistry B in 2020 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 6413-10-1

Facilitating Myers-Saito cyclization through acid-triggered tautomerization for the development of maleimide-based antitumor agents was written by Lu, Haotian;Ma, Hailong;Li, Baojun;Zhang, Mengsi;Chen, Huimin;Wang, Yue;Li, Xinxin;Ding, Yun;Hu, Aiguo. And the article was included in Journal of Materials Chemistry B in 2020.Application of 6413-10-1 The following contents are mentioned in the article:

Enyne-allene compounds undergo Myers-Saito cyclization at physiol. temperature to generate diradical intermediates that are capable of inducing DNA damage and cell death. The high reactivity of enyne-allene however limits their promising prospect as anticancer agents due to the spontaneous cyclization during storage and delivery. Regulating the cyclization process by taking advantage of the characteristics of a tumor cellular microenvironment, such as employing a low pH value to activate the cyclization process, is thus of essential importance. In this work, a novel enediyne (EDY) system with locked carbonyl groups was specifically designed and synthesized. Unlocking the protected carbonyl groups in the presence of acid would facilitate the rearrangement of propargyl moieties into an allene group, enabling the formation of an enyne-allene structure and occurrence of Myers-Saito cyclization. The pH-dependent diradical generation and DNA-cleavage ability of the designed EDY system were confirmed by ESR anal. and DNA gel electrophoresis. A promising cytotoxicity against HeLa cells with half inhibition concentrations (IC50) as low as 1.40μM was obtained, which was comparable to those of many com. applied anticancer drugs. Further in vitro experiments revealed that this EDY system induced intracellular DNA damage and subsequently resulted in S-phase arrest and cytotoxicity through programmed apoptosis. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Application of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Ren, Li-guo et al. published their research in Shiyou Huagong Gaodeng Xuexiao Xuebao in 2006 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.COA of Formula: C8H14O4

Phosphate-modified TiO2 solid acid catalysts was written by Ren, Li-guo;Gao, Wen-yi;Zhang, Xiao-li. And the article was included in Shiyou Huagong Gaodeng Xuexiao Xuebao in 2006.COA of Formula: C8H14O4 The following contents are mentioned in the article:

A phosphate-modified TiO2 solid acid catalyst was prepared from TiCl4 and H3PO4 by precipitation, aging, filtration, washing, drying, impregnation and calcination processes. The acidic property of catalyst was determined by Hammett indicator method and n-butylamine titration as well as pyridine adsorption FT-IR spectrometry. The characterization of the catalyst was performed using XRD, FT-IR, TG-DTA, and N2 adsorption methods. The effect of mass fraction of phosphate and calcination temperature on the acidic property, textural property and catalytic performance of phosphate-modified TiO2 solid acid catalysts was studied. TG-DTA curves and XRD patterns showed that phosphate could stabilize the anatase phase and prevent grains from growing. FT-IR spectra showed that phosphate is strongly bound to the TiO2 surface in a bidentate fashion. N2 adsorption and n-butylamine titration showed that surface area and pore volume as well as total acidity increased with the increase of mass fraction of phosphate when it was less than 7.5% and thereafter decreased. Hammett indicator method and pyridine adsorption FT-IR spectra showed that solid superacid was formed at 425-575°, and there were Lewis and Bronsted acidic centers on surface. The phosphate-modified TiO2 solid acid catalyst had good catalytic performance in the ketalization of Et acetoacetate and 1,2-ethylene glycol. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1COA of Formula: C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.COA of Formula: C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Routti, Heli et al. published their research in Environmental Science & Technology in 2016 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 6413-10-1

Environmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro was written by Routti, Heli;Lille-Langoey, Roger;Berg, Mari K.;Fink, Trine;Harju, Mikael;Kristiansen, Kurt;Rostkowski, Pawel;Rusten, Marte;Sylte, Ingebrigt;Oeygarden, Lene;Goksoeyr, Anders. And the article was included in Environmental Science & Technology in 2016.Related Products of 6413-10-1 The following contents are mentioned in the article:

The authors studied interactions between polar bear peroxisome proliferator-activated receptor gamma (pbPPARG) and selected compounds using a luciferase reporter assay and predictions through mol. docking. Furthermore, the authors studied adipogenesis by liver and adipose tissue extracts from a polar bear and three synthetic mixtures of contaminants in murine 3T3-L1 preadipocytes and polar bear adipose tissue-derived stem cells (pbASCs). PCB153 and p,p’-DDE antagonized pbPPARG, although their predicted receptor-ligand affinity was weak. PBDEs, tetrabromobisphenol A, and PCB170 had a weak agonistic effect on pbPPARG, while hexabromocyclododecane, bisphenol A, oxychlordane, and endosulfan were weak antagonists. pbPPARG-mediated luciferase activity was suppressed by synthetic contaminant mixtures reflecting levels measured in polar bear adipose tissue, as were transcript levels of PPARG and the PPARG target gene fatty acid binding protein 4 (FABP4) in pbASCs. Contaminant extracts from polar bear tissues enhanced triglyceride accumulation in murine 3T3-L1 cells and pbASCs, whereas triglyceride accumulation was not affected by the synthetic mixtures Chem. characterization of extracts using non-target methods revealed presence of exogenous compounds that have previously been reported to induce adipogenesis. These compounds included phthalates, tonalide, and nonylphenol. In conclusion, major legacy contaminants in polar bear adipose tissue exert antagonistic effects on PPARG, but adipogenesis by a mixture containing emerging compounds may be enhanced through PPARG or other pathways. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Related Products of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Truong, Thi Hanh et al. published their research in Molecular Catalysis in 2019 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Study on the HPA immobilisation on Al-SBA-15 support over Bronsted groups was written by Truong, Thi Hanh;Do, Van Cuong;Ngoc, Mai Do;Hung, Tran Quang;Doan, Huan Van;Nguyen, Thi Nhiem;Doan, Thi Hai;Le, Thi Hoai Nam;Nguyen, Tuyen Van;Bach, Long Giang;Tran, Quang Vinh. And the article was included in Molecular Catalysis in 2019.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

In this article, a significant aspect of Bronsted groups in the preparation of HPA/Al-SBA-15 catalyst by immobilizing heteropoly acid H3PW12O40 (HPA) to mesoporous Al-SBA-15 support was studied. The crucial factors affected the preparation such as functional groups formed on the support, the use of HPA type for the immobilization (com. catalyst or in-situ synthetic HPA), and Si/Al molar ratio of Al-SBA-15 were systematically investigated. The prepared catalysts were tested their performance in polar reagent reactions (fructone synthesis was chosen as an example) to show the effect of HPA after the immobilizaton. Here we tested the HPA content (by Energy-dispersive X-ray method), acidity (by temperature-programmed desorption of ammonia method) and the Et acetoacetate conversion in fructone synthesis to prove this concept. The other characterization methods such as small angle x-ray scattering, Fourier-transform IR spectroscopy, sp. surface area and pore volume also showed the properties change of materials before and after HPA immobilization. It was shown that the HPA/Al-SBA-15 sample prepared by using HPA com. catalyst and NH+4 ion-exchanged Bronsted groups of mesoporous Al-SBA-15 support (Si/Al molar ratio of 15) showed the highest acidity and catalytic activity (Et acetoacetate conversion of 93.49 wt%) in comparison to HPA com. catalyst as well as to the other catalysts. In addition, this catalyst also showed good catalytic stability after five reaction cycles with slightly reduction of activity, suggesting the prospect of employing HPA/Al-SBA-15 catalyst for organic synthesis of polar compounds This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Zhang, Fumin et al. published their research in Shiyou Huagong in 2005 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O4

Catalytic performance of phosphotungstic acid (salt) supported on SiO2 for acetalization of ethyl acetoacetate with glycol was written by Zhang, Fumin;Yuan, Chaoshu;Wang, Jun. And the article was included in Shiyou Huagong in 2005.Computed Properties of C8H14O4 The following contents are mentioned in the article:

12-Phosphotungstic acid (PW12) and/or its Cs salt and K salt supported on SiO2 were prepared by impregnation at ambient temperature The salts thus prepared were cesium tungstophosphate (Cs2.5H0.5PW12O40) and potassium tungstophosphate (K2.5H0.5PW12O40). Their catalytic performances in synthesis of fructone (i.e., 2-methyl-1,3-dioxolane-2-acetic acid Et ester), by acetalization of Et acetoacetate with glycol were investigated. Their properties were characterized by means of X-ray diffraction (XRD), N2 adsorption and Hammett indicator. The catalyst stability was evaluated by treatment with water, during which concentration of leached heteropoly acid or salt was measured by UV-visual spectrophotometer. The catalyst activity rose with increase of PW12 (Cs – or K -salt) loading, and conversion of Et acetoacetate became steady when loading was more than 30%. For PW12/SiO2, Cs2.5 H0.5 PW12/SiO2 and K2.5H0.3 PW12/SiO2 catalysts, selectivity of fructone was 97%, and conversions of Et acetoacetate was 69.8%, 68.6% and 68.4%, resp. The treatment of catalysts with water showed that deactivation of catalyst related correspondingly with the amount of leached active heteropoly species, and stabilities of three catalysts were in the order of 30% Cs2.5H0.5 PW12/SiO2 30% K2.5H0.5PW12/SiO2>>30% PW12/SiO2. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Computed Properties of C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Dik, Sander et al. published their research in Toxicological Sciences in 2014 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Evaluation of in silico models for the identification of respiratory sensitizers was written by Dik, Sander;Ezendam, Janine;Cunningham, Albert R.;Carrasquer, Carl Alex;van Loveren, Henk;Rorije, Emiel. And the article was included in Toxicological Sciences in 2014.Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

Low mol. weight (LMW) respiratory sensitizers can cause occupational asthma but due to a lack of adequate test methods, prospective identification of respiratory sensitizers is currently not possible. This article presents the evaluation of structure-activity relationship (SAR) models as potential methods to prospectively conclude on the sensitization potential of LMW chems. The predictive performance of the SARs calculated from their training sets was compared to their performance on a dataset of newly identified respiratory sensitizers and nonsensitizers, derived from literature. The predictivity of the available SARs for new substances was markedly lower than their published predictive performance. For that reason, no single SAR model can be considered sufficiently reliable to conclude on potential LMW respiratory sensitization properties of a substance. The individual applicability domains (ADs) of the models were analyzed for adequacies and deficiencies. Based on these findings, a tiered prediction approach is subsequently proposed. This approach combines the two SARs with the highest pos. and neg. predictivity taking into account model specific chem. AD issues. The tiered approach provided reliable predictions for one-third of the respiratory sensitizers and nonsensitizers of the external validation set compiled by the authors. For these chems., a pos. predictive value of 96% and a neg. predictive value of 89% were obtained. The tiered approach was not able to predict the other two-thirds of the chems., meaning that addnl. information is required and that there is an urgent need for other test methods, e.g., in chemico or in vitro, to reach a reliable conclusion. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Zhou, Shiyang et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2021 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 6413-10-1

Synthesis, activity and mechanism for double-ring conjugated enones was written by Zhou, Shiyang;Huang, Gangliang;Chen, Guangying;Liu, Jian. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.SDS of cas: 6413-10-1 The following contents are mentioned in the article:

The relationship between TLR4 and inflammation-related diseases has been paid more and more attention. The studies have shown that TLR4/NF-κB signaling pathway plays an important role in the transmission of inflammatory signals. A large number of pro-inflammatory factors, chemokines, adhesion factors, TLR4 and its ligands interact with each other, and jointly promote the development of diseases. In this work, 8 target compounds were synthesized to screen the inhibitory activity of TLR4 in vitro. The TLR4 inhibition test in vitro showed that the double-ring conjugated enones had a good inhibitory activity, and the IC50 value of compound 4f was 0.56 ± 0.10 μM, and it was superior to the pos. control methotrexate. To further study the anti-inflammatory effect and mechanism of double-ring conjugated enones by using LPS induced rat synovial cell inflammation model. The mechanism test showed that compound 4f could effectively promote the apoptosis of rat synovial cells, and the mechanism might be related to the up-regulation of the expression of apoptosis-related protein Caspase-3. In addition, compound 4f could significantly inhibit the increase of inflammatory factors TNF-α, IL-1β and IL-6 in rat synovial cells induced by LPS, showing a good anti-inflammatory activity. In the TLR4/NF-κB signaling pathway test of rat synovial cells, compound 4f can effectively regulate the expression levels of TLR4, MyD88, NF-κB and IκB related proteins in TLR4/NF-κB signaling pathway, which may be due to its inhibition of LPS-induced inflammation in rat synovial cells. At the same time, it inhibits the abnormal proliferation of cells and its important mechanism promoted of apoptosis. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1SDS of cas: 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Yang, Shuijin et al. published their research in Rare Metals (Beijing, China) in 2008 | CAS: 6413-10-1

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Catalytic synthesis of acetals and ketals with H3PW12O40/PAn was written by Yang, Shuijin;Zhang, Yijun;Du, Xinxian;Merle, Philippe G.. And the article was included in Rare Metals (Beijing, China) in 2008.Category: dioxole The following contents are mentioned in the article:

A new environmental friendly catalyst H3PW12O40/PAn (PAn = polyaniline) was prepared and identified by means of FT-IR, XRD, and TG/DTA. The optimum conditions have been found; i.e., the mass ratio of PAn to H3PW12O40 is 1:1.5, the volume of methanol is 20 mL, and the reflux reaction time is 3 h. The structural identity of Keggin units is preserved after the incorporation into polyaniline matrix. Catalytic activities of H3PW12O40/PAn in synthesizing 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane, cyclohexanone ethylene ketal, cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane, and 4-methyl-2-propyl-1,3-dioxolane were reported. It has been demonstrated that H3PW12O40/PAn is an excellent catalyst. Various factors concerned in these reactions were investigated. The optimum conditions are as follows: the molar ratio of aldehyde/ketone to glycol (r) is 1:1.5, the mass ratio of the catalyst used to the reactants is 0.6%, and the reaction time is 1.0 h. Under these conditions, the yield is as follows: 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 69.0%; 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 79.5%; cyclohexanone ethylene ketal, 78.9%; cyclohexanone 1,2-propanediol ketal, 85.3%; butanone ethylene ketal, 56.9%; butanone 1,2-propanediol ketal, 78.1%; 2-phenyl-1,3-dioxolane, 76.3%; 4-methyl-2-phenyl-1,3-dioxolane, 94.2%; 2-propyl-1,3-dioxolane, 70.7%; and 4-methyl-2-propyl-1,3-dioxolane, 79.2%. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Category: dioxole).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem